Herman J H, Khosla R C
Department of Internal Medicine, University of Cincinnati, Medical Sciences Center, OH 45267.
J Rheumatol. 1988 Dec;15(12):1818-26.
Laser therapy is being increasingly applied in the treatment of diverse forms of arthritis without a firm scientific basis for its safety or efficacy. Our study in part addresses this issue by assessing the in vitro effect of Nd:YAG laser radiation on mature normal bovine articular cartilage metabolism. Normal pulsed mode delivery of defined energy levels could be shown to consistently upregulate cartilage proteoglycan, collagen, noncollagen protein and DNA synthesis in the absence of histologic or biochemical evidence of enhanced matrix catabolism. Laser induced repair could be shown biochemically in in vitro model systems of enzymatically mediated cartilage matrix depletion. Results suggest that Nd:YAG radiation applied directly at surgery or via arthroscopy may provide a potential means of effecting cartilage healing. Further studies are necessary to substantiate such usage.
激光疗法在各种关节炎治疗中的应用日益增多，但其安全性和有效性尚无坚实的科学依据。我们的研究部分解决了这一问题，通过评估钕钇铝石榴石（Nd:YAG）激光辐射对成熟正常牛关节软骨代谢的体外影响。在没有组织学或生化证据表明基质分解代谢增强的情况下，可证明正常脉冲模式下特定能量水平的传递能够持续上调软骨蛋白聚糖、胶原蛋白、非胶原蛋白和DNA的合成。在酶介导的软骨基质消耗的体外模型系统中，可通过生化方法显示激光诱导的修复。结果表明，在手术中直接应用或通过关节镜应用Nd:YAG辐射可能提供一种促进软骨愈合的潜在方法。需要进一步研究来证实这种用法。
