Davis M A, Ettinger W H, Neuhaus J M
Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco 94143-0560.
J Rheumatol. 1988 Dec;15(12):1827-32.
The role of systemic/metabolic factors in the association of obesity with knee osteoarthritis (OA) was analyzed using radiographic data, metabolic measures, and blood pressure for 3885 American adults aged 45-74 from the U.S. National Health and Nutrition Examination Survey, 1971-1975 (NHANES I). Obesity was associated with both bilateral and unilateral OA, but more strongly with bilateral OA. Controlling for age, sex, serum cholesterol, serum uric acid, diabetes, body fat distribution, and blood pressure did not significantly reduce the association between obesity and knee OA. Findings from these data are not supportive of a metabolic link between obesity and knee OA.
利用来自1971 - 1975年美国国家健康和营养检查调查（NHANES I）的3885名45 - 74岁美国成年人的放射学数据、代谢指标和血压，分析了全身/代谢因素在肥胖与膝骨关节炎（OA）关联中的作用。肥胖与双侧和单侧OA均相关，但与双侧OA的关联更强。在控制年龄、性别、血清胆固醇、血清尿酸、糖尿病、体脂分布和血压后，肥胖与膝OA之间的关联并没有显著降低。这些数据的研究结果不支持肥胖与膝OA之间存在代谢联系。
