Rui Q Y, Li X, Zhang H B, Guo X M, Zheng N, Zhao L, Guo L Q, Li P H, Yue J J
School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China.
Department of Labor Hygiene and Environmental Hygiene, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020 Mar 20;38(3):237-240. doi: 10.3760/cma.j.cn121094-20190621-00259.
Environmental chemical pollutants are increasing, which brings various harms to human health. Epigenetics may be an important medium between exposure to environmental chemical contaminants and adverse health effects. Many environmental chemical pollutant exposures can regulate gene expression and promote disease occurrence and development through epigenetic mechanisms. This review outlines the mechanisms of epigenetics and the latest research advances in exposure and epigenetics of several environmental chemical substances (heavy metal arsenic, bisphenol A, dioctyl phthalate and benzene). To further understand and study the relationship between environmental chemical pollutant exposures and epigenetics in order to elucidate the mechanisms of disease occurrence and development.
环境化学污染物不断增加，给人类健康带来各种危害。表观遗传学可能是环境化学污染物暴露与不良健康影响之间的重要媒介。许多环境化学污染物暴露可通过表观遗传机制调节基因表达并促进疾病的发生和发展。本文综述了表观遗传学机制以及几种环境化学物质（重金属砷、双酚A、邻苯二甲酸二辛酯和苯）暴露与表观遗传学的最新研究进展。以便进一步了解和研究环境化学污染物暴露与表观遗传学之间的关系，从而阐明疾病发生和发展的机制。
