攻击性雄性大鼠后代的D2受体和转录因子EB表达改变，同时伴有抑郁和焦虑样行为。
Altered D2 receptor and transcription factor EB expression in offspring of aggressive male rats, along with having depressive and anxiety-like behaviors.
作者信息
Khalifeh Solmaz, Khodagholi Fariba, Zarrindast Mohammad-Reza, Alizadeh Rezvan, Asadi Sareh, Mohammadi Kamsorkh Hamed, Nasehi Mohammad, Ghadami Ali, Sadat-Shirazi Mitra-Sadat
机构信息
Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Int J Neurosci. 2021 Aug;131(8):789-799. doi: 10.1080/00207454.2020.1758086. Epub 2020 Apr 28.
MATERIALS AND METHODS
In this study we have evaluated the behavioral mood variations, and expression of DR-D2 and TFEB genes in the amygdala and PFC of aggressive male rats' offspring.
RESULTS
Anxiety and depression-like behaviors were observed, but intra-ventricle injection of DR-D2 antagonist (Sulpiride) has shown to be efficient in reducing negative behavioral changes in offspring. Furthermore, DR-D2 gene expression was increased in the amygdala and PFC of aggressive male rats' offspring, which the injection of Sulpiride decreased it significantly. TFEB gene expression was also decreased in the amygdala and PFC of aggressive male rats' offspring, but the blockade of DR-D2 had no effect on it.
CONCLUSIONS
The current data suggests the possible influence of dopaminergic receptors D2 and TFEB genes on the behavioral changes which is modified by having an aggressive father.
材料与方法
在本研究中，我们评估了攻击性雄性大鼠后代杏仁核和前额叶皮质中的行为情绪变化以及DR-D2和TFEB基因的表达。
结果
观察到焦虑和抑郁样行为，但脑室内注射DR-D2拮抗剂（舒必利）已显示出可有效减少后代的负面行为变化。此外，攻击性雄性大鼠后代的杏仁核和前额叶皮质中DR-D2基因表达增加，注射舒必利可使其显著降低。攻击性雄性大鼠后代的杏仁核和前额叶皮质中TFEB基因表达也降低，但阻断DR-D2对其没有影响。
结论
目前的数据表明多巴胺能受体D2和TFEB基因可能对因父亲具有攻击性而产生改变的行为变化有影响。
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