Department of Pharmacodynamics, Centre for Preclinical, Research and Technology (CePT), Medical University of Warsaw, Warsaw, Poland.
Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.
Subst Use Misuse. 2020;55(10):1610-1617. doi: 10.1080/10826084.2020.1753775. Epub 2020 Apr 20.
: Despite solutions presented by the European Union and national regulations introduced by many countries, the problem of mephedrone (4-MMC) is growing. : The aim of this study was to investigate the effect of regular mephedrone intake with other psychoactive substances on the clinical picture of patients, including self-harms and suicide attempts. : The study involved a group of 601 patients addicted to mephedrone who were admitted to a psychiatric hospital between 2010 and 2018 due to regular mephedrone intake. : There was a statistically significant relationship between sleep disorders and mephedrone combined with alcohol ( < .05) or cannabinols ( < .05). However, the highest number of statistically significant correlations was reported when mephedrone was combined with opioids. There was a growing year-on-year percentage of people who attempted suicide because of regular mephedrone intake ( < .001). The more psychoactive substances were combined with mephedrone, the greater the risk of attempted suicide ( < .01). 20% of the examined group were hospitalized several times. Among those hospitalized several times, significantly more people took more than one additional psychoactive substance ( < .01). : The more psychoactive substances combined with mephedrone, the more clinical symptoms are associated with it.
尽管欧盟和许多国家都提出了一些解决方案,但 4-甲基甲卡西酮(mephedrone,4-MMC)的问题仍在不断加剧。本研究旨在调查经常摄入 4-MMC 与其他精神活性物质共同作用对患者临床症状的影响,包括自伤和自杀企图。该研究涉及 2010 年至 2018 年间因经常摄入 4-MMC 而被收治于一家精神病院的 601 名 4-MMC 成瘾患者。睡眠障碍与 4-MMC 联合酒精( < .05)或大麻素( < .05)之间存在统计学显著关系。然而,当 4-MMC 与阿片类药物联合使用时,报告的统计学显著相关性数量最高。由于经常摄入 4-MMC 而自杀企图的人数逐年增加( < .001)。与 4-MMC 联合使用的精神活性物质越多,自杀企图的风险就越大( < .01)。被检查人群中有 20%的人多次住院。在多次住院的人群中,明显有更多的人同时使用了一种以上的其他精神活性物质( < .01)。与 4-MMC 联合使用的精神活性物质越多,与之相关的临床症状就越多。