Lee Jihei Sara, Jun Ikhyun, Kim Eung Kweon, Seo Kyoung Yul, Kim Tae-Im
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea.
Semin Ophthalmol. 2020 Feb 17;35(2):134-140. doi: 10.1080/08820538.2020.1755321. Epub 2020 Apr 18.
: Dry eye disease (DED) is a common condition that significantly lowers the quality of life. As the disease grows more prevalent, multiple commercial instruments have been developed to measure the ocular surface of dry eyes, but no single device has yet been successful in comprehensive measurements. The current study aimed to investigate the clinical accuracy and utility of the Antares topographer in the diagnosis of DED.: Thirty-three consecutive patients underwent analyses of their non-invasive first tear-film break-up time (NIF-BUT), tear meniscus height (TMH) and meibography with the Antares topographer. The meibography with the LipiView scan was conducted. Slit-lamp examinations were done for assessments of meibomian glands (MG) and fluorescein tear-film break-up time (FBUT). Schirmer 1 test was done. The Ocular Surface Disease Index (OSDI) scores were graded.: Thirty-three eyes of 33 patients (mean age 61.5 ± 10.6 years, range 37.5-76.4 years, 27.3% males) completed the study. According to the Antares measurements, the NIF-BUT of the patient population was 5.0 ± 3.4 seconds on average (1.1-15.0 seconds), and the TMH was 0.2 ± 0.1 mm at center (0.1-0.5 mm). The average OSDI score was 22.4 ± 16.6 points (0.0-79.5 points). When correlations were calculated, significant correlations were found between the NIF-BUT from the Antares topographer and FBUT (r = 0.538, = .001), and between MG dropout from the Antares topographer and that from the LipiView interferometer (r = 0.446, =.009). Antares NIF BUT and FBUT were in agreement with one another (95% limits of agreement (LOA) -5.04 ± 6.37, =.198) as were the infrared images from the Antares topographer and those from the LipiView interferometer (95% LOA -0.25 ± 0.35, =.073).: The Antares topographer is useful in the diagnosis of DED. Among its outputs, the NIF-BUT and MG dropout most closely correlated with currently accepted modes of diagnosis. However, concurrent clinical examinations are recommended for clinical follow-up.
干眼症（DED）是一种常见病症，会显著降低生活质量。随着该疾病日益普遍，已开发出多种商用仪器来测量干眼的眼表，但尚无单一设备能成功进行全面测量。本研究旨在探讨Antares地形图仪在诊断干眼症方面的临床准确性和实用性。
连续33例患者接受了使用Antares地形图仪对其无创首次泪膜破裂时间（NIF - BUT）、泪河高度（TMH）和睑板腺照相的分析。同时进行了LipiView扫描的睑板腺照相。通过裂隙灯检查评估睑板腺（MG）和荧光素泪膜破裂时间（FBUT）。进行了Schirmer 1试验。对眼表疾病指数（OSDI）评分进行了分级。
33例患者的33只眼（平均年龄61.5±10.6岁，范围37.5 - 76.4岁，男性占27.3%）完成了研究。根据Antares测量结果，患者群体的NIF - BUT平均为5.0±3.4秒（1.1 - 15.0秒），中央TMH为0.2±0.1毫米（0.1 - 0.5毫米）。平均OSDI评分为22.4±16.6分（0.0 - 79.5分）。计算相关性时，发现Antares地形图仪的NIF - BUT与FBUT之间存在显著相关性（r = 0.538，P = 0.001），以及Antares地形图仪的MG缺失与LipiView干涉仪的MG缺失之间存在显著相关性（r = 0.446，P = 0.009）。Antares NIF - BUT和FBUT相互一致（95%一致性界限（LOA）-5.04±6.37，P = 0.198），Antares地形图仪的红外图像与LipiView干涉仪的红外图像也相互一致（95% LOA -0.25±0.35，P = 0.073）。
Antares地形图仪在干眼症诊断中有用。在其各项输出结果中，NIF - BUT和MG缺失与目前公认的诊断方式相关性最强。然而，建议在临床随访中同时进行临床检查。
