ILC3s：进餐时维持肠道完整性的有节奏守护者。

ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime.

机构信息

Department of Immunology, IRCSS Bambino Gesù Children's Hospital, 00146 Rome, Italy.

Department of Experimental Medicine (DIMES) and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy; UOC Immunology Unit IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.

出版信息

Trends Immunol. 2020 May;41(5):364-366. doi: 10.1016/j.it.2020.03.011. Epub 2020 Apr 16.

DOI:10.1016/j.it.2020.03.011

PMID:32307240

Abstract

Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.

摘要

周期性地，在白天，肠道上皮屏障的通透性增加，允许营养物质吸收，必须得到补偿，以实现对潜在有害成分的增加保护。Seillet 等人证明，在进食时，肠神经元衍生的 VIP 通过诱导 ILC3 产生保护性的 IL-22 来促进预期的粘膜免疫。