作者回复：针对致死性心律失常的兰尼碱受体2靶向治疗。 - Suppr

Author's reply: The RyR2 - Targeting therapy against lethal arrhythmia.

作者信息

Kobayashi Shigeki, Yoshiga Yasuhiro, Yano Masafumi

机构信息

Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

出版信息

J Cardiol. 2020 Sep;76(3):323-324. doi: 10.1016/j.jjcc.2020.03.011. Epub 2020 Apr 16.

DOI:10.1016/j.jjcc.2020.03.011

PMID:32307305

Abstract

摘要

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Author's reply: The RyR2 - Targeting therapy against lethal arrhythmia.作者回复：针对致死性心律失常的兰尼碱受体2靶向治疗。

J Cardiol. 2020 Sep;76(3):323-324. doi: 10.1016/j.jjcc.2020.03.011. Epub 2020 Apr 16.

RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure.

J Mol Cell Cardiol. 2023 Sep;182:25-27. doi: 10.1016/j.yjmcc.2023.07.002. Epub 2023 Jul 6.

Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action.苯妥英钠降低心肌兰尼碱受体 2 的活性；其心脏保护作用的潜在机制。

Mol Pharmacol. 2020 Apr;97(4):250-258. doi: 10.1124/mol.119.117721. Epub 2020 Feb 3.

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.钙调蛋白对兰尼碱受体2（RyR2）的调节在控制心律、心力衰竭进展及丹曲林抗心律失常作用中所起的新作用。

Clin Exp Pharmacol Physiol. 2017 Jan;44(1):135-142. doi: 10.1111/1440-1681.12669.

Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca/calmodulin-dependent protein kinase IIδc transgenic mice.稳定心脏兰尼碱受体可预防 Ca/钙调蛋白依赖性蛋白激酶 IIδc 转基因小鼠心功能障碍和致死性心律失常的发生。

Biochem Biophys Res Commun. 2020 Apr 2;524(2):431-438. doi: 10.1016/j.bbrc.2020.01.107. Epub 2020 Jan 29.

A multicenter, randomized, double-blind, controlled study to evaluate the efficacy and safety of dantrolene on ventricular arrhythmia as well as mortality and morbidity in patients with chronic heart failure (SHO-IN trial): rationale and design.一项多中心、随机、双盲、对照研究，旨在评估丹曲林钠对慢性心力衰竭患者室性心律失常、死亡率和发病率的疗效和安全性（SHO-IN 试验）：基本原理和设计。

J Cardiol. 2020 Apr;75(4):454-461. doi: 10.1016/j.jjcc.2019.08.020. Epub 2019 Dec 20.

Ryanodine receptor-targeted anti-arrhythmic therapy.靶向兰尼碱受体的抗心律失常治疗

Ann N Y Acad Sci. 2005 Jun;1047:366-75. doi: 10.1196/annals.1341.032.

Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure.靶向兰尼碱受体病理性释放：临床前进展及其对心律失常和心力衰竭治疗的潜在影响。

Expert Opin Ther Targets. 2020 Jan;24(1):25-36. doi: 10.1080/14728222.2020.1708326. Epub 2020 Jan 3.

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.丹曲林对儿茶酚胺能多形性室性心动过速患者的抗心律失常作用及使用诱导多能干细胞模型复制其反应

PLoS One. 2015 May 8;10(5):e0125366. doi: 10.1371/journal.pone.0125366. eCollection 2015.

Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.丹曲林通过稳定压力超负荷诱导的衰竭心脏中的兰尼碱受体来预防室性心动过速。

Biochem Biophys Res Commun. 2020 Jan 1;521(1):57-63. doi: 10.1016/j.bbrc.2019.10.071. Epub 2019 Oct 18.

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Resveratrol inhibits the expression of RYR2 and is a potential treatment for pancreatic cancer.白藜芦醇抑制 RYR2 的表达，是治疗胰腺癌的一种潜在方法。

Naunyn Schmiedebergs Arch Pharmacol. 2022 Mar;395(3):315-324. doi: 10.1007/s00210-022-02203-9. Epub 2022 Jan 19.

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