Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Southern Iron Disorders Center, Birmingham, AL, USA.
Arch Immunol Ther Exp (Warsz). 2020 Apr 20;68(3):14. doi: 10.1007/s00005-020-00572-8.
We sought to determine whether HLA-A and -B type and haplotype frequencies differ between subgroups of adults with IgG subclass deficiency (IgGSD). We retrospectively compared type and haplotype frequencies of three subgroups of 269 unrelated adult IgGSD patients (70 subnormal IgG1; 121 subnormal IgG3; 78 subnormal IgG1/IgG3) and controls (1,321 for types; 751 for haplotypes). We selected types and haplotypes because their uncorrected frequencies differed significantly from controls in a previous adult IgGSD/common variable immunodeficiency cohort: A24; B14; B35; B40; B49; B50; B58; B62; A01,B08; A02,B44; A02,B60; A03,B07; A03,B14; A03,B44; A31,B40; and A32,B14. We used χ analysis (2 × 4 tables) to identify frequency differences across three subgroups and controls. If the null hypothesis was rejected (p < 0.05), we computed 2 × 2 χ tables to compare six combinations of subgroup and control frequencies [Bonferroni p < 0.0083 (< 0.05/6)]. Mean age was 48 ± 13 years; 82.2% were women. B35 and B40 frequencies were higher in subnormal IgG1 than subnormal IgG3 patients (0.1000 vs. 0.0248 and 0.0571 vs. 0.0083, respectively; p ≤ 0.0061). B62 frequencies were lower in three IgGSD subgroups than controls (p < 0.0001, respectively). A02, B44 frequency was higher in subnormal IgG1/IgG3 patients than controls (0.1282 vs. 0.0632, respectively; p = 0.0024). A02, B60 frequency was lower in subnormal IgG3 patients than controls (0.0 vs. 0.0233, respectively; p = 0.0051). HLA-B35 and -B40 frequencies differ significantly between some IgGSD subgroups. B62, A02, B44, and A02, B60 frequencies differ significantly between some IgGSD subgroups and controls.
我们试图确定人类白细胞抗原（HLA）-A 和 -B 型和单倍型频率在 IgG 亚类缺陷（IgGSD）成人亚组之间是否存在差异。我们回顾性比较了 269 例无亲缘关系的成年 IgGSD 患者（70 例 IgG1 亚正常；121 例 IgG3 亚正常；78 例 IgG1/IgG3 亚正常）的三个亚组和对照组（1321 种类型；751 种单倍型）的类型和单倍型频率。我们选择类型和单倍型是因为在之前的成年 IgGSD/常见可变免疫缺陷队列中，它们的未校正频率与对照组有显著差异：A24；B14；B35；B40；B49；B50；B58；B62；A01，B08；A02，B44；A02，B60；A03，B07；A03，B14；A03，B44；A31，B40；和 A32，B14。我们使用 χ 分析（2×4 表）来确定三个亚组和对照组之间的频率差异。如果零假设被拒绝（p<0.05），我们将计算 2×2 χ 表来比较亚组和对照组频率的六种组合[Bonferroni p<0.0083（<0.05/6）]。平均年龄为 48±13 岁；82.2%为女性。与 IgG3 亚正常患者相比，IgG1 亚正常患者的 B35 和 B40 频率更高（分别为 0.1000 比 0.0248 和 0.0571 比 0.0083；p≤0.0061）。与对照组相比，三组 IgGSD 亚组的 B62 频率较低（分别为 p<0.0001）。与对照组相比，IgG1/IgG3 亚正常患者的 A02，B44 频率更高（分别为 0.1282 比 0.0632；p=0.0024）。与对照组相比，IgG3 亚正常患者的 A02，B60 频率较低（分别为 0 比 0.0233；p=0.0051）。HLA-B35 和-B40 频率在某些 IgGSD 亚组之间存在显著差异。B62、A02、B44 和 A02、B60 频率在某些 IgGSD 亚组和对照组之间存在显著差异。
