Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Centre for Cancer Registries, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.
Int J Urol. 2020 Jun;27(6):538-542. doi: 10.1111/iju.14247. Epub 2020 Apr 19.
To investigate the clinical characteristics of patients with penile cancer in Japan using the nationwide hospital-based cancer registry database.
Using hospital-based cancer registry data, we described the distribution of age, pathology, tumor-node-metastases classification, and first-course treatment in patients treated between 2012 and 2015. We compared the patterns of first-line treatment between elderly and non-elderly patients.
A total of 1012 patients were diagnosed with squamous cell carcinoma among 1773 patients with penile tumors who registered under topography code C60. The median age at diagnosis was 74 years, and 85.9% of patients were aged >60 years. The most common pathology was usual-type squamous cell carcinoma (91.9%), followed by verrucous carcinoma (5.0%), sarcomatoid carcinoma (1.1%), papillary carcinoma (0.7%), basaloid carcinoma (0.6%), adenosquamous carcinoma (0.4%), warty carcinoma (0.2%) and mixed carcinoma (0.1%). A total of 61.3% of patients were diagnosed with localized disease. In contrast, the proportions of patients with lymph node and distant metastases were 27.5% and 2.1% at diagnosis, respectively. The proportion of patients who were treated with chemotherapy as the first-course treatment was significantly lower among elderly patients (≥80 years) with clinical stage III (27.6% vs 7.1%, P = 0.0312) and clinical stage IV (53.2% vs 14.3%, P = 0.0086).
Most penile cancer patients in Japan are diagnosed with usual-type squamous cell carcinoma, and those with human papilloma virus-related squamous cell carcinomas are <1%. Chemotherapy for advanced penile cancer is administered less in Japanese elderly (≥80 years) patients.
利用全国基于医院的癌症登记数据库，研究日本阴茎癌患者的临床特征。
使用基于医院的癌症登记数据，我们描述了 2012 年至 2015 年期间治疗的患者的年龄、病理学、肿瘤-淋巴结-转移分类和一线治疗分布。我们比较了老年和非老年患者的一线治疗模式。
在登记为 C60 解剖部位代码的 1773 例阴茎肿瘤患者中，共有 1012 例被诊断为鳞状细胞癌。诊断时的中位年龄为 74 岁，85.9%的患者年龄>60 岁。最常见的病理学类型是普通型鳞状细胞癌（91.9%），其次是疣状癌（5.0%）、肉瘤样癌（1.1%）、乳头状癌（0.7%）、基底细胞癌（0.6%）、腺鳞癌（0.4%）、疣状癌（0.2%）和混合癌（0.1%）。61.3%的患者被诊断为局限性疾病。相比之下，诊断时淋巴结转移和远处转移的患者比例分别为 27.5%和 2.1%。在临床分期 III 期（27.6% vs 7.1%，P=0.0312）和临床分期 IV 期（53.2% vs 14.3%，P=0.0086）中，老年（≥80 岁）患者接受一线化疗治疗的比例明显较低。
日本大多数阴茎癌患者被诊断为普通型鳞状细胞癌，与人类乳头瘤病毒相关的鳞状细胞癌<1%。对于晚期阴茎癌，日本老年（≥80 岁）患者接受化疗治疗的比例较低。
