Department of Neurology, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen, Guangdong, China.
Department of Radiology, Shenzhen Bao-An People's Hospital, Shenzhen, Guangdong, China.
Brain Behav. 2020 Jun;10(6):e01634. doi: 10.1002/brb3.1634. Epub 2020 Apr 19.
Our study aimed to confirm whether coagulation function of patients presenting with intracerebral hemorrhage (ICH) was associated with onset of cerebral microbleeds (CMBs).
A total of 174 patients with basal ganglia ICH were divided into CMBs and non-CMBs groups. Indicators of coagulation function and other clinical data that included fibrinogen (FBI), prothrombin time (PT), activated partial thromboplastin time (APTT), and the international normalized ratio (INR) were compared by univariate and multivariate analysis between the two groups. A receiver operating characteristic (ROC) curve was plotted to determine the predictive value of coagulation function indicators for CMBs.
Univariate analysis showed that APTT levels was significantly higher in the CMBs group than the non-CMBs group (30.20 ± 5.18 vs. 27.95 ± 4.19; p = .004), while there was no significant difference between PT, INR, and FBI. The proportion of male patients in the CMBs group was significantly higher than the non-CMBs group (76.58% vs. 52.38%, p = .001). Multifactor logistic regression analysis demonstrated that APTT and male gender were independent risk factors for CMBs in patients with ICH (OR 1.100, 95% CI: 1.026-1.180, p = .008; OR 2.957, 95% CI: 1.500-5.826, p = .002; respectively). ROC curve analysis indicated that the area under the curve of APTT and male gender for CMBs in patients with ICH was 0.641 and 0.621, respectively (p = .002 and .008; respectively).
APTT was an independent risk factor for CMBs in patients with ICH.
本研究旨在确认颅内出血（ICH）患者的凝血功能是否与脑微出血（CMBs）的发生有关。
将 174 例基底节区 ICH 患者分为 CMBs 组和非 CMBs 组。采用单因素和多因素分析比较两组患者的凝血功能指标及纤维蛋白原（FBI）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、国际标准化比值（INR）等其他临床资料。绘制受试者工作特征（ROC）曲线，确定凝血功能指标对 CMBs 的预测价值。
单因素分析显示，CMBs 组 APTT 水平明显高于非 CMBs 组（30.20±5.18比 27.95±4.19；p=0.004），而 PT、INR 和 FBI 两组间差异无统计学意义。CMBs 组男性患者比例明显高于非 CMBs 组（76.58%比 52.38%，p=0.001）。多因素 logistic 回归分析表明，APTT 和男性是 ICH 患者 CMBs 的独立危险因素（OR 1.100，95%CI：1.026-1.180，p=0.008；OR 2.957，95%CI：1.500-5.826，p=0.002）。ROC 曲线分析显示，APTT 和男性对 ICH 患者 CMBs 的曲线下面积分别为 0.641 和 0.621（p=0.002 和.008；分别）。
APTT 是 ICH 患者 CMBs 的独立危险因素。
