• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Ovarian Stromal Hyperplasia: A Rare Cause of Postmenopausal Hyperandrogenism.卵巢间质增生:绝经后高雄激素血症的罕见病因。
J Menopausal Med. 2020 Apr;26(1):39-43. doi: 10.6118/jmm.19012.
2
A rare case of postmenopausal hyperandrogenism due to ovarian hyperthecosis and hilus cell hyperplasia.一例罕见的绝经后高雄激素血症,由卵巢性索间质增生症和门细胞增生引起。
Post Reprod Health. 2022 Mar;28(1):51-55. doi: 10.1177/20533691211073451. Epub 2022 Feb 10.
3
Severe hyperandrogenemia in postmenopausal woman as a presentation of ovarian hyperthecosis. Case report and mini review of the literature.绝经后女性严重高雄激素血症表现为卵巢卵泡膜细胞增生症。病例报告及文献综述
Gynecol Endocrinol. 2017 Nov;33(11):836-839. doi: 10.1080/09513590.2017.1337094. Epub 2017 Jun 11.
4
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor.一名患有卵巢间质卵泡膜细胞增生症以及高雄激素血症、胰岛素抵抗和黑棘皮症综合征患者的胰岛素抵抗。一例可能存在内源性卵巢因素病例的报告。
J Reprod Med. 1995 Jun;40(6):491-4.
5
Virilization due to ovarian hyperthecosis in a postmenopausal woman.一名绝经后女性因卵巢卵泡膜细胞增生症出现男性化。
Gynecol Endocrinol. 1988 Dec;2(4):331-8. doi: 10.3109/09513598809107656.
6
Diffuse stromal Leydig cell hyperplasia: a unique cause of postmenopausal hyperandrogenism and virilization.弥漫性间质莱迪希细胞增生:绝经后高雄激素血症和男性化的独特病因。
Mayo Clin Proc. 2000 Mar;75(3):288-92. doi: 10.4065/75.3.288.
7
A Rare Case of Hyperandrogenism Due to Fibrothecoma and Leydig Cell Tumor in a Postmenopausal Woman With Adrenal Adenoma: A Case Report and Literature Review.一名绝经后女性肾上腺腺瘤合并纤维卵泡膜瘤和睾丸间质细胞瘤导致高雄激素血症的罕见病例:病例报告及文献综述
Cureus. 2023 Aug 9;15(8):e43180. doi: 10.7759/cureus.43180. eCollection 2023 Aug.
8
Postmenopausal hyperandrogenism of ovarian origin. A clinicopathologic study of four cases.卵巢来源的绝经后高雄激素血症。4例临床病理研究。
Gynecol Obstet Invest. 1992;34(1):52-6. doi: 10.1159/000292725.
9
Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis.绝经后女性因卵巢间质卵泡膜细胞增生症出现男性化。
Postgrad Med J. 1991 Mar;67(785):304-6. doi: 10.1136/pgmj.67.785.304.
10
Diagnostic Challenges in Ovarian Hyperthecosis: Clinical Presentation with Subdiagnostic Testosterone Levels.卵巢泡膜细胞增生症的诊断挑战:睾酮水平未达诊断标准时的临床表现
Case Rep Endocrinol. 2022 Jan 18;2022:9998807. doi: 10.1155/2022/9998807. eCollection 2022.

引用本文的文献

1
Inadequate Ovarian Function Suppression with GnRH Agonists and Subsequent Bilateral Salpingo-Oophorectomy Revealing Ovarian Stromal Hyperplasia in a Premenopausal Woman with Early-Stage, Hormone Receptor-Positive Breast Cancer: A Case Report.GnRH 激动剂对卵巢功能抑制不足及随后双侧输卵管卵巢切除术揭示了一名绝经前早期激素受体阳性乳腺癌女性的卵巢间质增生:一例报告
Case Rep Oncol. 2025 May 19;18(1):864-871. doi: 10.1159/000546479. eCollection 2025 Jan-Dec.
2
Hyperplastic ovarian stromal cells express genes associated to tumor progression: a case study.增生性卵巢基质细胞表达与肿瘤进展相关的基因:病例研究。
BMC Vet Res. 2024 Sep 28;20(1):439. doi: 10.1186/s12917-024-04275-6.
3

本文引用的文献

1
An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report.一名绝经后多毛症和高雄激素血症女性患者的超声检查阴性的卵巢莱迪希细胞瘤:病例报告
Medicine (Baltimore). 2018 Mar;97(10):e0093. doi: 10.1097/MD.0000000000010093.
2
Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.临床病例研讨会:绝经后雄激素过多症-卵巢性索间质肿瘤的诊断和治疗挑战。
Clin Endocrinol (Oxf). 2018 Jan;88(1):13-20. doi: 10.1111/cen.13492. Epub 2017 Nov 7.
3
Severe hyperandrogenemia in postmenopausal woman as a presentation of ovarian hyperthecosis. Case report and mini review of the literature.
Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system.
罕见病例:左炔诺孕酮宫内节育系统治疗后出现持续性子宫内膜增生,同时并存卵巢布伦纳瘤和卵巢间质增生。
BMJ Case Rep. 2022 Dec 21;15(12):e252391. doi: 10.1136/bcr-2022-252391.
4
[Virilization and metabolic disease in postmenopausal women related to ovarian hyperplasia and hypertecosis].绝经后女性的男性化与代谢性疾病与卵巢增生和功能亢进相关
Rev Fac Cien Med Univ Nac Cordoba. 2021 Jun 28;78(2):193-196. doi: 10.31053/1853.0605.v78.n2.32136.
绝经后女性严重高雄激素血症表现为卵巢卵泡膜细胞增生症。病例报告及文献综述
Gynecol Endocrinol. 2017 Nov;33(11):836-839. doi: 10.1080/09513590.2017.1337094. Epub 2017 Jun 11.
4
Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.鉴别绝经后妇女的促性腺激素肿瘤和卵巢性索间质增生:临床资料、激素谱和影像学研究。
Eur J Endocrinol. 2017 Jul;177(1):93-102. doi: 10.1530/EJE-17-0111. Epub 2017 Apr 21.
5
Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife.绝经前女性的睾酮水平与中年非酒精性脂肪性肝病相关。
Am J Gastroenterol. 2017 May;112(5):755-762. doi: 10.1038/ajg.2017.44. Epub 2017 Mar 14.
6
Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin.促性腺激素释放激素激动剂治疗卵巢源性高雄激素血症绝经后妇女。
J Clin Endocrinol Metab. 2011 May;96(5):1197-201. doi: 10.1210/jc.2010-1991. Epub 2011 Feb 9.
7
Long term health consequences of polycystic ovarian syndrome: a review analysis.多囊卵巢综合征的长期健康后果:一项综述分析
Hippokratia. 2009 Apr;13(2):90-2.
8
Hyperandrogenism after transfer of topical testosterone gel: case report and review of published and unpublished studies.
Hum Reprod. 2009 Feb;24(2):425-8. doi: 10.1093/humrep/den372. Epub 2008 Oct 23.
9
[Nonalcoholic steatohepatitis associated with ovarian stromal hyperplasia].[与卵巢间质增生相关的非酒精性脂肪性肝炎]
Gastroenterol Hepatol. 2005 Aug-Sep;28(7):375-7. doi: 10.1157/13077757.
10
The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women.低剂量地塞米松抑制试验在女性高雄激素血症鉴别诊断中的价值
J Clin Endocrinol Metab. 2003 Jun;88(6):2634-43. doi: 10.1210/jc.2002-020922.

卵巢间质增生:绝经后高雄激素血症的罕见病因。

Ovarian Stromal Hyperplasia: A Rare Cause of Postmenopausal Hyperandrogenism.

作者信息

Lozoya Araque Teresa, Monfort Ortiz Isauro Rogelio, Martín González José Enrique, Jiménez García Alenda, Navarro Hidalgo Inmaculada, Andrade Gamarra Verónica, Parrell Soler Cecilia, Gil Raga Fernando

机构信息

Department of Obstetrics and Gynecology, Manises Hospital, Valencia, Spain.

Department of Obstetrics and Gynecology, La Fe University Hospital, Valencia, Spain.

出版信息

J Menopausal Med. 2020 Apr;26(1):39-43. doi: 10.6118/jmm.19012.

DOI:10.6118/jmm.19012
PMID:32307950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7160587/
Abstract

Ovarian hyperthecosis and ovarian stromal hyperplasia (OSH) are two uncommon non-neoplastic causes of ovarian hyperandrogenism, whose etiology is still unknown. These conditions are characterized by obesity, hyperinsulinemia, acanthosis nigricans, and even virilization, mainly in postmenopausal women. Here we have reported the case of a 67-year-old patient with a diagnosis of OSH, which was resolved after bilateral laparoscopic oophorectomy. In this case report, we have discussed two different conditions posing a diagnostic challenge and requiring a high index of suspicion.

摘要

卵巢泡膜细胞增生症和卵巢间质增生(OSH)是卵巢雄激素过多症的两种罕见的非肿瘤性病因,其病因仍不明。这些病症的特征为肥胖、高胰岛素血症、黑棘皮症,甚至男性化,主要见于绝经后女性。在此,我们报告了一例67岁诊断为OSH的患者,该患者在双侧腹腔镜卵巢切除术后病情得到缓解。在本病例报告中,我们讨论了两种造成诊断困难且需要高度怀疑指数的不同病症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e43/7160587/3c1be2704a3e/jmm-26-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e43/7160587/3c1be2704a3e/jmm-26-39-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e43/7160587/3c1be2704a3e/jmm-26-39-g001.jpg