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盖尔特恩茎（葛根）通过调节神经细胞黏附分子（NCAM）和生长相关蛋白43（GAP - 43）的表达改善慢性不可预测温和应激（CUMS）小鼠的抑郁行为。

Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP-43 Expression.

作者信息

Zhao Ya-Nan, Cao Ya-Fei, Zhang Yan-Hong, Lu Ye, Ping Xin, Qin Shao-Kun, Liu Shu-Ning, Chu Li, Sun Guo-Qiang, Pei Lin

机构信息

School of Chinese Medicine, North China University of Science and Technology, Tangshan, Hebei 063210, China.

Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050051, China.

出版信息

Evid Based Complement Alternat Med. 2020 Mar 30;2020:3056954. doi: 10.1155/2020/3056954. eCollection 2020.

DOI:10.1155/2020/3056954
PMID:32308703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7149381/
Abstract

BACKGROUND

Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. . This study's aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. . HG aqueous extract was administered intragastrically for 21 days after the chronic unpredictable mild stress (CUMS) procedure, and its effect on memory, learning, and emotion was assessed using animal behavioral tests. HG aqueous extract was characterized using HPLC. Immunofluorescence was used to measure the neural cell-adhesion molecule (NCAM) and growth-associated protein-43 (GAP-43) expression.

RESULTS

Depression-like behaviors increased in the CUMS group compared with the control (CON) group, while they were reduced in the high-dose HG (H-HG) and fluoxetine (FLU) groups ( < 0.05). Additionally, NCAM and GAP-43 expression was reduced in the CUMS group compared with the CON group, but it increased in the H-HG and FLU groups ( < 0.05).

CONCLUSIONS

These findings show the potential antidepressant effects of HG through mechanisms involving regulation of NCAM and GAP-43. This provides a new theoretical basis for its potential application as an antidepressant-like agent.

摘要

背景

葛藤茎（葛根[HG]）是一种在东亚用于治疗精神症状的传统中药。然而，普遍缺乏科学证据来支持这一传统说法。本研究的目的是研究HG的抗抑郁作用，并进一步探索其作用可能涉及的分子机制。在慢性不可预测轻度应激（CUMS）程序后，连续21天灌胃给予HG水提取物，并使用动物行为测试评估其对记忆、学习和情绪的影响。使用高效液相色谱法对HG水提取物进行表征。采用免疫荧光法检测神经细胞黏附分子（NCAM）和生长相关蛋白43（GAP - 43）的表达。

结果

与对照组（CON）相比，CUMS组的抑郁样行为增加，而高剂量HG（H - HG）组和氟西汀（FLU）组的抑郁样行为减少（<0.05）。此外，与CON组相比，CUMS组中NCAM和GAP - 43的表达降低，但在H - HG组和FLU组中增加（<0.05）。

结论

这些发现表明HG通过涉及调节NCAM和GAP - 43的机制具有潜在的抗抑郁作用。这为其作为抗抑郁样药物的潜在应用提供了新的理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3726/7149381/aceed6d0593d/ECAM2020-3056954.011.jpg
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