Zhu Bin-Bin, Zhou Jie, Zheng Jiao, Zhang Yue, Wan Ting, Huang Xiao-Dan, Lin Lin, Jin Xiu-Ming
Eye Center, the Affiliated Second Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China.
Int J Ophthalmol. 2020 Mar 18;13(3):493-502. doi: 10.18240/ijo.2020.03.19. eCollection 2020.
Corneal graft melting is a severe complication of keratoplasty. This review is to summarize the incidence, the pathogenesis, the risk factors, the prognosis and the prevention of corneal graft melting after keratoplasty. We systematically searched PubMed, Web of Science and WanFang database to retrieve potentially eligible articles about relevant clinical reports and animal experiments. We read the full texts to identify eligible articles. The selection of studies and data extraction were performed independently by two reviewers. In conclusion, the pathogenesis of corneal graft melting is complicated, and many risk factors are closely related to corneal graft melting. Analysis of pathogenesis and risk factors of corneal graft melting can facilitate the development of targeted therapies to better guide clinical practice.
角膜移植片融解是角膜移植术的一种严重并发症。本综述旨在总结角膜移植术后角膜移植片融解的发生率、发病机制、危险因素、预后及预防措施。我们系统检索了PubMed、Web of Science和万方数据库，以获取有关相关临床报告和动物实验的潜在合格文章。我们阅读全文以确定合格文章。研究的筛选和数据提取由两名审阅者独立进行。总之，角膜移植片融解的发病机制复杂，许多危险因素与角膜移植片融解密切相关。分析角膜移植片融解的发病机制和危险因素有助于开发针对性治疗方法，以更好地指导临床实践。
