Pontes Flávia S C, de Souza Lucas L, Vulcão Élida N C, de Abreu Michelle C, Menezes Sarah N, Rezende Diogo, Pontes Hélder A R
Oral Surgery and Pathology Department, João de Barros Barreto University Hospital/Federal University of Pará, Belém, Brazil.
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Head Neck. 2020 Sep;42(9):2626-2634. doi: 10.1002/hed.26160. Epub 2020 Apr 20.
The aim of this study was to integrate the available data published on Liposarcomas (LPSs) of the oral cavity into an analysis of its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in January 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Forty-five publications (104 LPSs) were included. The lesion was more prevalent in males from the fifth to seventh decades of life. Treatment (P = .03) and distant metastasis (P = .0001) were independently associated with survival. A lower possibility of recurrence was statistically associated with age (younger patients) (P = .03), tumor size (smaller than 2.8 cm) (P = .001), and treatment (radical surgery) (P = .04). LPS presents a good survival for patients after 5 years of follow-up (66.4%). Patients who were treated with conservative surgery and presented with distant metastasis showed poor prognosis.
本研究的目的是将已发表的关于口腔脂肪肉瘤（LPSs）的现有数据整合起来，分析其临床特征、治疗方式和预后因素。2019年1月进行了电子检索。纳入标准包括有足够临床和组织学信息以确诊的出版物。共纳入45篇出版物（104例LPSs）。该病变在5至70岁男性中更为常见。治疗（P = .03）和远处转移（P = .0001）与生存率独立相关。复发可能性较低在统计学上与年龄（年轻患者）（P = .03）、肿瘤大小（小于2.8 cm）（P = .001）和治疗（根治性手术）（P = .04）相关。随访5年后，LPS患者的生存率良好（66.4%）。接受保守手术且出现远处转移的患者预后较差。
