移植大鼠结肠癌的免疫预防与治疗
Immunoprophylaxis and therapy of grafted rat colonic carcinoma.
作者信息
Martin M S, Martin F, Justrabo E, Michel M F, Lagneau A
出版信息
Gut. 1977 Mar;18(3):232-5. doi: 10.1136/gut.18.3.232.
Two independent lines of chemically-induced colonic carcinoma, serially graftable in syngeneic rats, have been used to investigate the effects of immunoprophylaxis and immunotherapy. Rats were immunised by various procedures, including BCG, irradiated tumour grafts, and cancer cells treated by mitomycin and neuraminidase. A partial inhibition of tumour growth was observed in one of the four protocols. On the other hand, a significant enhancement of tumour growth was obtained in two other experiments.
已使用两种可在同基因大鼠中连续移植的化学诱导结肠癌独立系来研究免疫预防和免疫治疗的效果。通过包括卡介苗、经辐照的肿瘤移植物以及经丝裂霉素和神经氨酸酶处理的癌细胞等各种程序对大鼠进行免疫。在四个方案中的一个中观察到肿瘤生长有部分抑制。另一方面，在另外两个实验中肿瘤生长得到了显著增强。
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