Zou Xian, Shi Longshun, Zhu Guohua, Zhu Liguo, Bao Jiandong, Fan Jun, Hu Yonghong, Zhou Bin, Lv Zhongwei
Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine.
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu.
Medicine (Baltimore). 2020 Apr;99(16):e19840. doi: 10.1097/MD.0000000000019840.
To determine the levels of parathyroid hormone (PTH) in the fluids of various tissues for identification of parathyroid glands during thyroidectomy.Our study comprised 31 patients with thyroid cancer who underwent lobectomy with central compartment dissection at our hospital from October 2014 to February 2015. A total of 186 tissue samples, including 28 from parathyroid glands and 158 from non-parathyroid tissues, were obtained during the operations. Tissue fluids were collected via fine-needle aspiration to measure PTH levels; the tissue was punctured 3 times with a 26-gauge syringe needle and washed with 0.5 mL normal saline. Tissues were also prepared for pathological examination.PTH concentrations were significantly higher in parathyroid tissues than non-parathyroid tissues. None of the patients had irremediable parathyroid dysfunction after surgical resection.Use of fine-needle aspiration for quantification of PTH levels in tissue fluids rapidly, safely, and effectively identifies the parathyroid glands during thyroidectomy.
为了确定甲状腺切除术中各种组织液中甲状旁腺激素（PTH）的水平，以识别甲状旁腺。我们的研究纳入了2014年10月至2015年2月在我院接受甲状腺叶切除加中央区淋巴结清扫术的31例甲状腺癌患者。手术过程中总共获取了186份组织样本，其中28份来自甲状旁腺，158份来自非甲状旁腺组织。通过细针穿刺收集组织液以测量PTH水平；用26号注射器针头对组织穿刺3次，并用0.5mL生理盐水冲洗。组织也被制备用于病理检查。甲状旁腺组织中的PTH浓度显著高于非甲状旁腺组织。手术后所有患者均未出现不可补救的甲状旁腺功能障碍。在甲状腺切除术中，使用细针穿刺对组织液中的PTH水平进行定量能够快速、安全且有效地识别甲状旁腺。
