肝素、肝素激活的酶与血小板。

Heparin, heparin-activated enzymes and platelets.

作者信息

Ham J M, Lawrence J C

出版信息

Haemostasis. 1977;6(1):26-34. doi: 10.1159/000214162.

Abstract

This review summarises evidence supporting the view that the therapeutic anticoagulant properties of heparin are related to its physiological function in the organism, especially its activation of lipoprotein lipase and lecithinase. The conflicting results obtained from studies of the effect of heparin on platelet function are discussed, together with reasons for these differences of opinion. Finally, a hypothesis which links heparin, heparin-activated enzymes and platelet function is proposed, this hypothesis being complementary to the current views concerning the activation by heparin of the inhibitor of activated factor X.

摘要

本综述总结了支持以下观点的证据

肝素的治疗性抗凝特性与其在机体中的生理功能相关，尤其是其对脂蛋白脂肪酶和卵磷脂酶的激活作用。文中讨论了关于肝素对血小板功能影响的研究中所获得的相互矛盾的结果，以及这些不同观点产生的原因。最后，提出了一个将肝素、肝素激活的酶与血小板功能联系起来的假说，该假说与目前关于肝素激活活化因子X抑制剂的观点相辅相成。