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[一例双侧三叉神经痛及基于手术发现的可能发病机制]

[A Case of Bilateral Trigeminal Neuralgia and the Possible Onset Mechanisms Based on the Operative Findings].

作者信息

Tanaka Masahiro, Toyooka Terushige, Matsuzaki Toshinori, Yamakawa Kota, Akasu Isao, Kitagawa Ryo, Sakai Jun, Numazawa Shinichi, Itoh Yasunobu, Watanabe Sadayoshi, Otani Naoki, Wada Kojiro, Mori Kentaro

机构信息

Department of Neurosurgery, Tokyo General Hospital.

出版信息

No Shinkei Geka. 2020 Apr;48(4):317-322. doi: 10.11477/mf.1436204184.

Abstract

Several cases of bilateral trigeminal neuralgia(TN)have been reported;however, the possible onset mechanism has rarely been discussed. We encountered a case of bilateral TN occurring in two stages. A 64-year-old woman presented with left TN. Magnetic resonance imaging showed the transverse pontine vein adhering to the left trigeminal root and superior cerebellar artery adhering to the right trigeminal root;however, no symptoms were noted. Immediately after microvascular decompression(MVD)on the left side, TN disappeared completely. However, 2 years postoperatively, the patient presented with right TN. The second MVD surgery revealed that the right cerebellar surface severely adhered to the dura mater, particularly under the surface of the tentorium. The arachnoid membrane at the cerebellopontine angle was slightly adhered. The patient was completely free from pain after the second MVD. The intraoperative findings suggested that the brain stem may have shifted and the cerebellopontine cistern may have narrowed because of cerebellar adhesion to the surrounding structures and arachnoid adhesion. We speculate that such structural changes in the posterior fossa after the first operation may have caused the asymptomatic vascular adhesion to change into the symptomatic offending adhesion over time.

摘要

已有多例双侧三叉神经痛(TN)的病例报道;然而,其可能的发病机制鲜有讨论。我们遇到一例双侧TN分两个阶段发生的病例。一名64岁女性出现左侧TN。磁共振成像显示横窦桥静脉附着于左侧三叉神经根,小脑上动脉附着于右侧三叉神经根;然而,未发现症状。左侧微血管减压术(MVD)后,TN立即完全消失。然而,术后2年,患者出现右侧TN。第二次MVD手术显示右侧小脑表面与硬脑膜严重粘连,尤其是小脑幕表面下方。桥小脑角处的蛛网膜有轻度粘连。第二次MVD术后患者疼痛完全消失。术中发现提示,由于小脑与周围结构粘连及蛛网膜粘连,脑干可能发生了移位,桥小脑池可能变窄。我们推测,首次手术后后颅窝的这种结构变化可能导致无症状的血管粘连随着时间的推移转变为有症状的致痛粘连。

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