接受检查点抑制剂治疗的患者出现孤立性促肾上腺皮质激素缺乏症。
Isolated adrenocorticotrophic hormone deficiency in a patient treated with checkpoint inhibitor therapy.
作者信息
Ramani Azaan, Maloney Taylor, Mills Brooke, Mazharuddin Samir, Mennel Robert G
机构信息
Department of Internal Medicine, Baylor University Medical CenterDallasTexas.
Department of Oncology, Baylor University Medical CenterDallasTexas.
出版信息
Proc (Bayl Univ Med Cent). 2019 Dec 23;33(2):251-253. doi: 10.1080/08998280.2019.1698217. eCollection 2020 Apr.
Abstract
Treatment of advanced melanoma has significantly improved with the advent of checkpoint inhibitor therapy. With the widespread use of these agents, side effects are being increasingly recognized, including immune-related adverse events. We report the onset of adrenal insufficiency in a patient with advanced melanoma who was exposed to two checkpoint inhibitors: ipilimumab and nivolumab. His symptoms initially resolved with steroid replacement but he was unable to be weaned off hormone replacement and required long-term oral hydrocortisone treatment.
摘要
随着检查点抑制剂疗法的出现，晚期黑色素瘤的治疗有了显著改善。随着这些药物的广泛使用，副作用越来越受到关注，包括免疫相关不良事件。我们报告了一名晚期黑色素瘤患者在接受两种检查点抑制剂（伊匹单抗和纳武单抗）治疗后发生肾上腺功能不全的情况。他的症状最初通过类固醇替代治疗得到缓解，但无法停用激素替代治疗，需要长期口服氢化可的松治疗。
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