Department of Nephrology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ther Apher Dial. 2021 Feb;25(1):50-54. doi: 10.1111/1744-9987.13505. Epub 2020 May 4.
The aim of this study was to investigate the clinical features, risk factors and outcomes of tuberculosis spondylitis (TBS) in patients on hemodialysis (HD). We systematically reviewed medical records from 12 HD patients with TBS admitted to our hospital from April 2008 to April 2018. A total of 120 age- and sex-matched HD patients without infections were randomly selected as controls. The incidence of TBS in our patient group was 1.5/1000 per year. The average duration from initial symptoms to diagnosis was 45.4 days (range, 11-180 days). Neurosurgery was performed in 4 (33.3%) patients. TBS was cured or improved in 11 (91.7%) patients. HD patients with TBS had significantly lower albumin and Hb levels than controls (P = .03 and P = .01). These findings indicated that lower albumin and Hb levels were possible risk factors for TBS in patients on HD, most HD patients with TBS had a good outcome after anti-TB therapy with or without surgery.
本研究旨在探讨血液透析（HD）患者中结核病性脊柱炎（TBS）的临床特征、危险因素和转归。我们系统地回顾了 2008 年 4 月至 2018 年 4 月期间我院收治的 12 例 TBS 合并 HD 的患者的病历。随机选择了 120 例年龄和性别相匹配的无感染 HD 患者作为对照组。我们患者组 TBS 的发病率为 1.5/1000 人/年。从首发症状到诊断的平均时间为 45.4 天（范围 11-180 天）。4 例（33.3%）患者接受了神经外科手术。11 例（91.7%）TBS 患者治愈或好转。TBS 组的 HD 患者白蛋白和 Hb 水平明显低于对照组（P =.03 和 P =.01）。这些发现表明，低白蛋白和 Hb 水平可能是 HD 患者发生 TBS 的危险因素，大多数 TBS 合并 HD 的患者在接受抗结核治疗（联合或不联合手术）后，预后良好。
