Wang Qi, Liu Yan, Zhao Yun, Sun Li-Zhong, Wang Lin-Xuan, Han Mei, Mi Fang-Lin
Dept. of Stomatology, North Sichuan Medical College, Nanchong 637000, China.
Dept. of Prosthodontics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Apr 1;38(2):218-223. doi: 10.7518/hxkq.2020.02.018.
Erythropoietin-producing hepatomocellular receptors and their receptor-interacting proteins (Eph/ephrin) can participate in the regulation of growth and development and promote the development of diseases through short-distance signal transduction between cells. To study the mechanism of Eph/ephrin and oral-related diseases, we provided a new theoretical basis and a strategy for the treatment of oral diseases. The Eph/ephrin pathway has been used to regulate oral diseases, especially in periodontal disease prevention, orthodontic bone reconstruction, and biological treatment of oral tumors. This paper reviews the research progress of Eph/ephrin pathway in oral-related diseases.
促红细胞生成素产生性肝细胞受体及其受体相互作用蛋白(Eph/ephrin)可通过细胞间短距离信号转导参与生长发育调控并促进疾病发展。为研究Eph/ephrin与口腔相关疾病的机制,我们为口腔疾病的治疗提供了新的理论基础和策略。Eph/ephrin通路已被用于调控口腔疾病,尤其是在牙周病预防、正畸骨重建及口腔肿瘤的生物治疗方面。本文综述了Eph/ephrin通路在口腔相关疾病中的研究进展。