JumpstartMD, 350 Lorton Ave, Burlingame, CA 94010, USA.
Department of Surgery, Stanford University Medical Center, Stanford, CA, USA.
J Obes. 2020 Jan 21;2020:8026016. doi: 10.1155/2020/8026016. eCollection 2020.
Commercial weight loss programs provide valuable consumer options for those desiring support. Several commercial programs are reported to produce ≥3-fold greater weight loss than self-directed dieting. The effectiveness of JumpstartMD, a commercial pay-as-you-go program that emphasizes a low-to-very-low-carbohydrate real-food diet and optional pharmacologic treatment without prepackaged meals or meal replacement, has not previously been described.
Completer and last observation carried forward (LOCF) of clinic-measured weight loss (kg) in 18,769 female and 3638 male JumpstartMD participants.
Completers lost (mean ± SE) 8.7 ± 0.04 kg, 9.5 ± 0.04% with 44.5 ± 0.5% achieving ≥10% weight loss at 3 months (mo, = 14,999 completers); 11.8 ± 0.1 kg, 12.6 ± 0.1% with 66.4 ± 0.6% achieving ≥10% weight loss at 6 mo ( = 11,805); and 11.5 ± 0.2 kg, 12.0 ± 0.2% with 57.6 ± 0.9% achieving ≥10% weight loss at 12 mo ( = 8514). LOCF estimates were -6.5 ± 0.03 kg, -7.2 ± 0.03% with 27.1 ± 0.3% achieving ≥10% weight loss at 3 mo; -7.7 ± 0.04 kg, -8.5 ± 0.04% with 36.3 ± 0.3% achieving ≥10% weight loss at 6 mo; and -7.7 ± 0.1 kg, -8.4 ± 0.1% with 34.6 ± 0.3% achieving ≥10% weight loss after 12 mo. Frequent health coach meetings was a major determinant of weight loss, with women and men attending ≥75% of their weekly appointments losing 8.8 ± 0.04 and 11.9 ± 0.1 kg, respectively, after 3 mo, 13.1 ± 0.1 and 16.5 ± 0.3 kg after 6 mo, and 16.5 ± 0.3 and 19.4 ± 0.8 kg after 12 mo. Phentermine and phendimetrazine had a minor effect in women only at 1 (6.1% greater weight loss than untreated), 2 (4.1%), and 3 mo (1.2%), but treated patients showed longer enrollment than nontreated during the first 3 (females: +0.4 ± 0.01; males: +0.3 ± 0.04 mo), 6 (females: +1.1 ± 0.04; males: +1.0 ± 0.1 mo), and 12 mo (females: +2.7 ± 0.1; males: +2.4 ± 0.2 mo). JumpstartMD produced generally greater weight loss than published reports for other real-food and prepackaged-meal commercial programs and somewhat greater or comparable losses to meal replacement diets.
A one-on-one medically supervised program that emphasized real low-carbohydrate foods produced effective weight loss, particularly in those attending ≥75% of their weekly appointments.
商业减肥计划为那些希望获得支持的人提供了有价值的消费者选择。据报道，一些商业计划产生的体重减轻量是自我导向节食的三倍以上。JumpstartMD 是一种商业付费即走计划，强调低至非常低碳水化合物的真实食物饮食和可选的药物治疗，而无需预先包装的膳食或代餐，其效果以前尚未描述过。
18769 名女性和 3638 名男性 JumpstartMD 参与者的临床测量体重减轻（kg）的完成者和最后观察前进（LOCF）。
完成者体重减轻（平均值±SE）分别为 8.7±0.04kg、9.5±0.04%，其中 44.5±0.5%的人在 3 个月（ = 14999 名完成者）时体重减轻≥10%；11.8±0.1kg、12.6±0.1%，其中 66.4±0.6%的人在 6 个月（ = 11805 名）时体重减轻≥10%；11.5±0.2kg、12.0±0.2%，其中 57.6±0.9%的人在 12 个月（ = 8514 名）时体重减轻≥10%。LOCF 估计值为-6.5±0.03kg、-7.2±0.03%，其中 27.1±0.3%的人在 3 个月时体重减轻≥10%；-7.7±0.04kg、-8.5±0.04%，其中 36.3±0.3%的人在 6 个月时体重减轻≥10%；-7.7±0.1kg、-8.4±0.1%，其中 34.6±0.3%的人在 12 个月时体重减轻≥10%。频繁的健康教练会议是体重减轻的主要决定因素，女性和男性分别参加≥75%的每周预约，在 3 个月后体重减轻 8.8±0.04kg 和 11.9±0.1kg，在 6 个月后体重减轻 13.1±0.1kg 和 16.5±0.3kg，在 12 个月后体重减轻 16.5±0.3kg 和 19.4±0.8kg。苯丁胺和苯丙胺在女性中仅在第 1 个月（未治疗者体重减轻 6.1%）、第 2 个月（4.1%）和第 3 个月（1.2%）有较小的影响，但治疗患者在最初 3 个月（女性：+0.4±0.01；男性：+0.3±0.04 个月）、6 个月（女性：+1.1±0.04；男性：+1.0±0.1 个月）和 12 个月（女性：+2.7±0.1；男性：+2.4±0.2 个月）的登记时间比未治疗者长。JumpstartMD 产生的体重减轻通常比其他真实食物和预先包装膳食的商业计划的报告更有效，并且与代餐饮食的减轻量相当或更大。
强调真实低碳水化合物食物的一对一医学监督计划产生了有效的体重减轻，特别是在参加≥75%每周预约的人群中。
