地中海贫血患儿的生长模式及其与血清铁蛋白的相关性。

Growth pattern in thalassemic children and their correlation with serum ferritin.

作者信息

Rathaur Vyas Kumar, Imran Ayesha, Pathania Monika

机构信息

Department of Pediatrics, K.D. Medical College, Mathura, UP, India.

Department of Pediatrics, Government Doon Medical College, Dehradun, Uttarakhand, India.

出版信息

J Family Med Prim Care. 2020 Feb 28;9(2):1166-1169. doi: 10.4103/jfmpc.jfmpc_951_19. eCollection 2020 Feb.

DOI:10.4103/jfmpc.jfmpc_951_19

PMID:32318486

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7114017/

Abstract

BACKGROUND

This study was conducted to determine the effects of iron overload on growth and correlation of serum ferritin and growth disorders in children with thalassemia.

METHODOLOGY

It was a crosssectional study conducted from January to June 2019 on 70 children age up to 18 years with transfusiondependent thalassemia. Detailed history, demographics, anthropometric parameters, clinical and laboratory details were evaluated. Data was analyzed by statistical package of social sciences (SPSS) software. Logistic regression model was used to determine the correlation between serum ferritin with short stature.

RESULTS

It included 46 male and 24 female, of which 65.71% had short stature and 77% were underweight. The mean serum ferritin level was 1,560.9 μg/L, 45.71% have serum ferritin level > 2,500 μg/L, and 65.71% had hemoglobin levels of 5-8 g/dL before transfusion. The receiver operating curve value of serum ferritin was 1,107 μg/L with respect to the incidence of short stature and there was significant correlation between serum ferritin level and the incidences of short stature ( = 0.001).

CONCLUSION

There was a significant correlation between serum ferritin level and growth disorders.

摘要

背景

本研究旨在确定铁过载对地中海贫血患儿生长的影响以及血清铁蛋白与生长障碍的相关性。

方法

这是一项横断面研究，于2019年1月至6月对70名18岁以下的输血依赖型地中海贫血患儿进行。评估了详细病史、人口统计学、人体测量参数、临床和实验室细节。数据采用社会科学统计软件包（SPSS）进行分析。采用逻辑回归模型确定血清铁蛋白与身材矮小之间的相关性。

结果

其中男性46例，女性24例，65.71%身材矮小，77%体重不足。血清铁蛋白平均水平为1560.9μg/L，45.71%的血清铁蛋白水平>2500μg/L，65.71%输血前血红蛋白水平为5-8g/dL。血清铁蛋白的受试者工作特征曲线值为1107μg/L，与身材矮小的发生率相关，血清铁蛋白水平与身材矮小的发生率之间存在显著相关性（P = 0.001）。