Oliveira Rui C, Abrantes Ana Margarida, Tralhão José Guilherme, Botelho Maria Filomena
Biophysics Unit Faculty of Medicine University of Coimbra Coimbra Portugal.
Pathology Department University Hospital (CHUC) Coimbra Portugal.
Animal Model Exp Med. 2020 Mar 11;3(1):1-8. doi: 10.1002/ame2.12102. eCollection 2020 Mar.
Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
结直肠癌是一项全球性的健康负担，其发病率和死亡率都很高，尤其是在疾病的晚期阶段。临床前模型对于发现和验证早期及特异性生物标志物以及新的治疗靶点非常重要且有价值。为了实现这一点，动物模型必须在疾病的所有阶段复制其临床演变过程。在本文中，我们回顾了现有的小鼠模型，及其在复制人类癌症疾病进展方面的优缺点，主要侧重于原位模型。
