Lindberg Margaretha, Franklin Oskar, Svensson Johan, Franklin Karl A
Department of Surgical and Perioperative Sciences, Surgery, Umeå University, SE-901 85, Umeå, Sweden.
Department of Statistics, Umeå School of Business, Economics and Statistics, Umeå University, Umeå, Sweden.
Int J Colorectal Dis. 2020 Jul;35(7):1265-1272. doi: 10.1007/s00384-020-03580-4. Epub 2020 Apr 21.
Postoperative pain is a keystone in perioperative programs, as pain negatively impacts recovery. This study aimed to evaluate pain after elective colorectal surgery and to identify risk factors for postoperative pain.
This prospective cohort study comprised consecutive patients undergoing elective colorectal surgery within the Enhanced Recovery after Surgery (ERAS) perioperative program between March 2013 and April 2017. The numeric rating scale (NRS) was used to estimate maximum pain. Logistic regression was used to model associations with the type of surgery, age, gender, and comorbidities.
The cohort comprised 434 of 459 eligible patients. On the day of surgery to postoperative day 3, 50-64% of patients reported moderate to severe pain (NRS 4-10). Postoperative pain was similar for open and minimally invasive rectal surgery, while patients undergoing minimally invasive colonic surgery experienced more pain on the day of surgery and less pain on postoperative days 2 and 3 vs. open colonic surgery. Younger age was associated with more pain every postoperative day and by 0.7 NRS/10 years (95% CI 0.5-0.9, P < 0.001) on the day of surgery, while having diabetes type 2 was associated with less postoperative pain by - 1.3 NRS (95% CI - 2.4 to - 0.2) on the day of surgery.
The majority, and young patients in particular, experience moderate to severe pain after open and minimally invasive colorectal surgery, despite following ERAS perioperative program. There is a need for effective and individualized analgesia after colorectal surgery, since the individual pain response to surgery is difficult to predict.
术后疼痛是围手术期方案的关键要素,因为疼痛会对恢复产生负面影响。本研究旨在评估择期结直肠手术后的疼痛情况,并确定术后疼痛的危险因素。
这项前瞻性队列研究纳入了2013年3月至2017年4月期间在手术后加速康复(ERAS)围手术期方案下接受择期结直肠手术的连续患者。采用数字评分量表(NRS)评估最大疼痛程度。使用逻辑回归模型分析手术类型、年龄、性别和合并症之间的关联。
符合条件的459例患者中,434例纳入队列。在手术当天至术后第3天,50%至64%的患者报告有中度至重度疼痛(NRS 4 - 10)。开放和微创直肠手术的术后疼痛情况相似,而与开放结肠手术相比,接受微创结肠手术的患者在手术当天疼痛更明显,术后第2天和第3天疼痛较轻。年龄较小与术后每天疼痛更明显相关,手术当天每10岁疼痛程度增加0.7 NRS(95% CI 为0.5 - 0.9,P < 0.001),而患有2型糖尿病的患者在手术当天术后疼痛程度减轻1.3 NRS(95% CI 为 - 2.4至 - 0.2)。
尽管遵循了ERAS围手术期方案,但大多数患者,尤其是年轻患者,在开放和微创结直肠手术后仍经历中度至重度疼痛。由于个体对手术的疼痛反应难以预测,结直肠手术后需要有效的个体化镇痛措施。