Department of Public Health, University of Naples Federico II, Naples, Italy.
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Diagn Cytopathol. 2020 Aug;48(8):759-764. doi: 10.1002/dc.24438. Epub 2020 Apr 22.
Carcinomas do rarely metastasize to the finger. Non-small-cell lung cancer is most frequently involved. To date, only a few cases have been reported, on histology. Here we describe the cytological features of a metastatic lung adenocarcinoma case to the phalanx of the right forefinger as initial manifestation of the neoplastic disease in a 69-years-old woman. The cytological microscopic findings, complemented by a wide array of ancillary techniques, were confirmed by histology. Neoplastic cells were positive for cytokeratin 7 (CK7) and thyroid transcription factor 1 (TTF-1), harboring, in tissue and in bloodstream samples, an uncommon epidermal growth factor receptor (EGFR) exon 20 p.S768_D760DUP, detected by next generation sequencing (NGS) and liquid biopsy. Cytology corroborated by immunocytochemistry, NGS, and liquid biopsy is a modern approach to provide diagnostic and therapeutic information even in rare and challenging cases.
癌很少转移到手指。非小细胞肺癌最常受累。迄今为止，只有少数病例在组织学上有报道。在这里，我们描述了一例右食指指骨转移性肺腺癌的细胞学特征，这是一例 69 岁女性肿瘤疾病的最初表现。细胞学显微镜检查结果，辅以广泛的辅助技术，通过组织学得到证实。肿瘤细胞 CK7（细胞角蛋白 7）和甲状腺转录因子 1（TTF-1）阳性，在组织和血液样本中存在罕见的表皮生长因子受体（EGFR）外显子 20 p.S768_D760DUP，通过下一代测序（NGS）和液体活检检测到。细胞学结合免疫细胞化学、NGS 和液体活检是一种现代方法，可以提供诊断和治疗信息，即使在罕见和具有挑战性的情况下也是如此。
