Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Centro Nazionale Prevenzione delle Malattie e Promozione della Salute, Istituto Superiore di Sanità, Roma, Italy.
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):403-409. doi: 10.1080/21678421.2020.1752250. Epub 2020 Apr 22.
: Since the observation of several deaths from amyotrophic lateral sclerosis (ALS) among Italian professional soccer players, an association between ALS and soccer has been postulated. The objective of the study is to investigate the association between professional soccer and the risk of ALS in a large cohort of former professional soccer players with prolonged follow-up. : All professional soccer players practicing in the period 1959-2000 were identified through the archives of an Italian soccer cards publisher. For each player, date and place of birth, playing role, and team history were recorded. Each player was followed since 15 years of age. Incident ALS cases were all soccer players first diagnosed during the period 1959-2018. The expected incidence rate was the number of ALS cases/100,000 person-years expected in the cohort. SIR was the ratio between observed and expected incidence rate. : 34 ALS cases were detected. The number of expected cases was 17.8. The SIR was 1.91 (95% CI 1.32-2.67) in the entire sample and 4.66 (95% CI 2.66-7.57) in subjects aged less than 45 years. The mean age at diagnosis was 45.0 years. Compared to the mean age of onset of ALS in the general population (65.2 years), the disease in former soccer players occurred 20.2 years earlier. : Professional soccer players are at higher risk of developing ALS than the general population. Soccer players with ALS develop the disease at a younger than expected age.
: 自意大利职业足球运动员中观察到几例肌萎缩侧索硬化症（ALS）死亡以来，人们推测 ALS 与足球之间存在关联。本研究旨在通过对长期随访的大量前职业足球运动员队列进行研究，调查职业足球与 ALS 风险之间的关联。: 通过一家意大利足球卡出版商的档案，确定了 1959-2000 年期间在意大利从事职业足球的所有运动员。记录了每位运动员的出生日期、出生地、比赛角色和球队历史。每位运动员从 15 岁开始随访。新确诊的 ALS 病例均为 1959-2018 年期间首次确诊的足球运动员。预期发病率为队列中每 100,000 人年预计出现的 ALS 病例数。SIR 是观察到的发病率与预期发病率的比值。: 共发现 34 例 ALS 病例。预计病例数为 17.8 例。整个样本的 SIR 为 1.91（95%CI 1.32-2.67），45 岁以下人群的 SIR 为 4.66（95%CI 2.66-7.57）。诊断时的平均年龄为 45.0 岁。与普通人群（65.2 岁）中 ALS 的平均发病年龄相比，前足球运动员发病年龄提前了 20.2 岁。: 职业足球运动员患 ALS 的风险高于普通人群。患有 ALS 的足球运动员发病年龄比预期年轻。
