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视神经脊髓炎谱系疾病并发后部可逆性脑病综合征作为首发表现。

Neuromyelitis Optica Spectrum Disorder Complicated by Posterior Reversible Encephalopathy Syndrome as an Initial Manifestation.

机构信息

Department of Neurology and Strokology, Nagasaki University Hospital, Japan.

出版信息

Intern Med. 2020 Aug 1;59(15):1887-1890. doi: 10.2169/internalmedicine.4226-19. Epub 2020 Apr 23.

DOI:10.2169/internalmedicine.4226-19
PMID:32321890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7474992/
Abstract

A 25-year-old woman was admitted to our hospital due to tonic convulsion with severe headache after having experienced symptoms of nausea and vomiting for a month. Brain magnetic resonance imaging showed extensive symmetrical lesions in the cortical and subcortical areas of parieto-occipital lobes and basal ganglia, consistent with typical characteristics of posterior reversible encephalopathy syndrome (PRES). Furthermore, some residual lesions in the left side of dorsal medulla oblongata and central area of the cervical spinal cord along with the presence of serum anti-aquaporin-4 antibody yielded the diagnosis of neuromyelitis optica spectrum disorder (NMOSD). We herein discuss the mechanism by which PRES may occur together with NMOSD.

摘要

一位 25 岁女性因出现恶心和呕吐症状 1 个月后发生强直阵挛性抽搐伴严重头痛而被收入我院。脑部磁共振成像显示顶枕叶和基底节区皮质和皮质下区域广泛对称病变，符合典型的后部可逆性脑病综合征（PRES）特征。此外，延髓背侧左半侧和颈脊髓中央区存在一些残留病变，同时血清抗水通道蛋白-4 抗体阳性，诊断为视神经脊髓炎谱系疾病（NMOSD）。本文讨论 PRES 与 NMOSD 同时发生的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/7474992/34fc28c0d645/1349-7235-59-1887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/7474992/c707cbabd27e/1349-7235-59-1887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/7474992/34fc28c0d645/1349-7235-59-1887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/7474992/c707cbabd27e/1349-7235-59-1887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ffd/7474992/34fc28c0d645/1349-7235-59-1887-g002.jpg

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Sci Transl Med. 2017 Jul 5;9(397). doi: 10.1126/scitranslmed.aai9111.
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