Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China.
Department of Thyroid Breast Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Mediators Inflamm. 2020 Apr 6;2020:2369279. doi: 10.1155/2020/2369279. eCollection 2020.
The interleukin-12 (IL-12) family consists of four members, namely, IL-12, IL-23, IL-27, and IL-35. The aim of this study was to examine the expression of circulating IL-12, IL-23, IL-27, and IL-35 in hypertensive patients.
Blood samples were collected from hypertensive patients and nonhypertensive (control) subjects, and protein multifactorial monitor kits were used to measure the plasma IL-12, IL-23, IL-27, and IL-35 levels in each sample. In addition, all enrolled subjects underwent ambulatory blood pressure monitoring (ABPM) and vascular stiffness.
Hypertensive patients exhibited higher IL-12, IL-23, and IL-27 levels and lower IL-35 levels than control subjects; IL-12, IL-23, and IL-27 levels were positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), while IL-35 levels were negatively correlated with SBP and DBP. IL-12, IL-23, and IL-27 levels gradually increased in patients with grade I, II, and III hypertension, while IL-35 levels gradually reduced. According to the ABPM results, hypertensive patients were divided into the dipper and nondipper hypertension groups; IL-12, IL-23, IL-27, and IL-35 levels showed no differences between the two groups, but IL-12, IL-23, and IL-27 levels in both groups increased compared with those in the control group, while IL-35 levels decreased. Additionally, the expression of these IL-12 family members was influenced by many clinical factors and was independently associated with the occurrence of carotid atherosclerotic plaques.
The changes in IL-12, IL-23, IL-27, and IL-35 levels were not associated with the presence of the nondipper type but were closely associated with the development of carotid atherosclerotic plaque in hypertensive patients.
白细胞介素-12（IL-12）家族由四个成员组成，分别是 IL-12、IL-23、IL-27 和 IL-35。本研究旨在探讨高血压患者循环中 IL-12、IL-23、IL-27 和 IL-35 的表达。
采集高血压患者和非高血压（对照）受试者的血样，使用蛋白多因子监测试剂盒测量每个样本中的血浆 IL-12、IL-23、IL-27 和 IL-35 水平。此外，所有入组受试者均进行了动态血压监测（ABPM）和血管僵硬度检查。
与对照组相比，高血压患者的 IL-12、IL-23 和 IL-27 水平较高，而 IL-35 水平较低；IL-12、IL-23 和 IL-27 水平与收缩压（SBP）和舒张压（DBP）均呈正相关，而 IL-35 水平与 SBP 和 DBP 呈负相关。随着 I 级、II 级和 III 级高血压患者的病情进展，IL-12、IL-23 和 IL-27 水平逐渐升高，而 IL-35 水平逐渐降低。根据 ABPM 结果，将高血压患者分为杓型和非杓型高血压组；两组间 IL-12、IL-23、IL-27 和 IL-35 水平无差异，但两组均较对照组升高，而 IL-35 水平降低。此外，这些 IL-12 家族成员的表达受多种临床因素影响，并与颈动脉粥样硬化斑块的发生独立相关。
IL-12、IL-23、IL-27 和 IL-35 水平的变化与非杓型无关，而与高血压患者颈动脉粥样硬化斑块的发生密切相关。
