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病毒感染期间，含酰基辅酶A结合结构域3在膜接触位点的新作用。

Emerging Role for Acyl-CoA Binding Domain Containing 3 at Membrane Contact Sites During Viral Infection.

作者信息

Lu Yue, Song Siqi, Zhang Leiliang

机构信息

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China.

Institute of Basic Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.

出版信息

Front Microbiol. 2020 Apr 8;11:608. doi: 10.3389/fmicb.2020.00608. eCollection 2020.

DOI:10.3389/fmicb.2020.00608
PMID:32322249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7156584/
Abstract

Acyl-coenzyme A binding domain containing 3 (ACBD3) is a multifunctional protein residing in the Golgi apparatus and is involved in several signaling pathways. The current knowledge on ACBD3 has been extended to virology. ACBD3 has recently emerged as a key factor subverted by viruses, including kobuvirus, enterovirus, and hepatitis C virus. The ACBD3-PI4KB complex is critical for the role of ACBD3 in viral replication. In most cases, ACBD3 plays a positive role in viral infection. ACBD3 associates with viral 3A proteins from a variety of family members at membrane contact sites (MCSs), which are used by diverse viruses to ensure lipid transfer to replication organelles (ROs). In this review, we discuss the mechanisms underlying the involvement of ACBD3 in viral infection at MCSs. Our review will highlight the current research and reveal potential avenues for future research.

摘要

含酰基辅酶A结合结构域3（ACBD3）是一种存在于高尔基体中的多功能蛋白质，参与多种信号通路。目前关于ACBD3的知识已扩展到病毒学领域。ACBD3最近已成为包括杯状病毒、肠道病毒和丙型肝炎病毒在内的多种病毒破坏的关键因子。ACBD3-PI4KB复合物对于ACBD3在病毒复制中的作用至关重要。在大多数情况下，ACBD3在病毒感染中起积极作用。ACBD3在膜接触位点（MCSs）与多种病毒家族成员的病毒3A蛋白相互作用，不同病毒利用这些位点确保脂质转移至复制细胞器（ROs）。在本综述中，我们讨论了ACBD3在MCSs参与病毒感染的潜在机制。我们的综述将突出当前研究并揭示未来研究的潜在途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87d/7156584/2a467c7fc608/fmicb-11-00608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87d/7156584/2a467c7fc608/fmicb-11-00608-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b87d/7156584/2a467c7fc608/fmicb-11-00608-g001.jpg

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