Ding Dandan, Guo Jiayin, Sun Hui, Yang Jing
Cuiying Biomedical Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, 730030, China.
Mol Biol Rep. 2025 Apr 30;52(1):440. doi: 10.1007/s11033-025-10547-7.
Salmonella is one of the major pathogens responsible for foodborne illnesses worldwide, characterized by diverse serotypes and a broad host range. As an intracellular bacterium, Salmonella invades host cells and establishes a protected niche known as the Salmonella-containing vacuoles (SCVs), which provide a suitable environment for intracellular survival. Rab GTPases, key regulators of intracellular membrane trafficking, play a crucial role in the biogenesis and dynamics of SCVs. Through its type III secretion systems (T3SSs), Salmonella delivers a repertoire of effector proteins into host cells, which modulate the activity of Rab GTPases and alter membrane trafficking to facilitate SCVs formation and maintenance. This review summarizes recent advances in understanding how Salmonella effectors manipulate Rab GTPases to promote intracellular survival and evade host innate immune responses.
沙门氏菌是全球食源性疾病的主要病原体之一，具有多种血清型和广泛的宿主范围。作为一种胞内细菌，沙门氏菌侵入宿主细胞并建立一个被称为含沙门氏菌液泡（SCV）的受保护微环境，为胞内存活提供了适宜的环境。Rab GTP酶是细胞内膜运输的关键调节因子，在SCV的生物发生和动态变化中起关键作用。沙门氏菌通过其三型分泌系统（T3SS）将一系列效应蛋白输送到宿主细胞中，这些效应蛋白调节Rab GTP酶的活性并改变膜运输，以促进SCV的形成和维持。本综述总结了在理解沙门氏菌效应蛋白如何操纵Rab GTP酶以促进胞内存活和逃避宿主固有免疫反应方面的最新进展。
