Kokkali Stefania, Andriotis Efthymios, Katsarou Elena, Theocharis Angelos, Drizou Maria, Magou Elpida, Tzovaras Alexandros, Ardavanis Alexandros
First Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, Greece.
Radiology Department, Saint-Savvas Cancer Hospital, Athens, Greece.
Radiol Case Rep. 2020 Apr 16;15(6):780-783. doi: 10.1016/j.radcr.2020.03.020. eCollection 2020 Jun.
Although brain metastases from bone and soft tissue sarcoma are uncommon, advances in sarcoma treatment have led to an increasing incidence of them. We present a 23-year-old male with a history of metastatic femoral osteosarcoma, who presented with headache and unsteady gait and was diagnosed with a cerebellar metastasis. CT scan revealed a mass in the left cerebellar parenchyma with large intralesional central calcification and perilesional edema. Corticosteroid treatment led to neurological symptoms resolution, with a rapid tapering. The patient had also lung metastases and we opted to administer systemic treatment with the tyrosine kinase inhibitor cabozantinib. Given the relative radioresistance of osteosarcomas, the patient did not receive radiation therapy.
尽管骨与软组织肉瘤的脑转移并不常见，但肉瘤治疗的进展导致其发生率不断上升。我们报告一名23岁男性，有转移性股骨骨肉瘤病史，出现头痛和步态不稳，被诊断为小脑转移瘤。CT扫描显示左小脑实质内有一肿块，病灶内有大量中央钙化及病灶周围水肿。皮质类固醇治疗使神经症状缓解，并迅速减量。该患者还有肺转移，我们选择使用酪氨酸激酶抑制剂卡博替尼进行全身治疗。鉴于骨肉瘤相对抗拒放疗，该患者未接受放射治疗。
