小儿创伤性脊髓损伤的病因及治疗综述
A Review on the Etiology and Management of Pediatric Traumatic Spinal Cord Injuries.
作者信息
Benmelouka Amira, Shamseldin Laila Salah, Nourelden Anas Zakarya, Negida Ahmed
机构信息
Faculty of Medicine, University of Algiers, Algiers, Algeria.
Faculty of Medicine, Tanta University, Tanta, Egypt.
出版信息
Adv J Emerg Med. 2019 Oct 10;4(2):e28. doi: 10.22114/ajem.v0i0.256. eCollection 2020 Spring.
CONTEXT
Pediatric traumatic spinal cord injury (SCI) is an uncommon presentation in the emergency department. Severe injuries are associated with devastating outcomes and complications, resulting in high costs to both the society and the economic system.
EVIDENCE ACQUISITION
The data on pediatric traumatic spinal cord injuries has been narratively reviewed.
RESULTS
Pediatric SCI is a life-threatening emergency leading to serious outcomes and high mortality in children if not managed promptly. Pediatric SCI can impose many challenges to neurosurgeons and caregivers because of the lack of large studies with high evidence level and specific guidelines in terms of diagnosis, initial management and of in-hospital treatment options. Several novel potential treatment options for SCI have been developed and are currently under investigation. However, research studies into this field have been limited by the ethical and methodological challenges.
CONCLUSION
Future research is needed to investigate the safety and efficacy of the recent uprising neurodegenerative techniques in SCI population. Owing to the current limitations, there is a need to develop novel trial methodologies that can overcome the current methodological and ethical limitations.
背景
小儿创伤性脊髓损伤（SCI）在急诊科并不常见。严重损伤会导致毁灭性的后果和并发症，给社会和经济系统带来高昂成本。
证据获取
对小儿创伤性脊髓损伤的数据进行了叙述性综述。
结果
小儿脊髓损伤是一种危及生命的急症，如果不及时处理，会导致儿童出现严重后果和高死亡率。由于缺乏关于诊断、初始处理及住院治疗选择方面的高证据水平的大型研究和具体指南，小儿脊髓损伤会给神经外科医生和护理人员带来诸多挑战。已经开发出几种新型的脊髓损伤潜在治疗方案，目前正在研究中。然而，该领域的研究受到伦理和方法学挑战的限制。
结论
未来需要开展研究，以调查近期新兴的神经退行性技术在脊髓损伤人群中的安全性和有效性。鉴于当前的局限性，有必要开发能够克服当前方法学和伦理局限性的新型试验方法。
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