溃疡性结肠炎和克罗恩病患者自我报告结局（PRO-2）与内镜及组织学特征的相关性
Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients.
作者信息
Dragasevic Sanja, Sokic-Milutinovic Aleksandra, Stojkovic Lalosevic Milica, Milovanovic Tamara, Djuranovic Srdjan, Jovanovic Ivan, Rajic Sanja, Stojkovic Mirjana, Milicic Biljana, Kmezic Stefan, Oluic Branislav, Aleksic Marko, Pavlovic Markovic Aleksandra, Popovic Dragan
机构信息
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia.
School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
出版信息
Gastroenterol Res Pract. 2020 Apr 2;2020:2065383. doi: 10.1155/2020/2065383. eCollection 2020.
METHODS
A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system.
RESULTS
We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease ( = -0.67; = -0.72), while positive correlation was found in ulcerative colitis ( = 0.84; = 0.75). . Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.
方法
在一家三级医疗转诊中心，对连续的新诊断炎症性肠病患者进行了一项横断面研究。初始评估包括患者报告的大便频率子评分和直肠出血的结果。使用溃疡性结肠炎的梅奥评分系统和克罗恩病的简单内镜评分来确定内镜活动度。使用经过验证的数字评分系统评估组织病理学活动度。
结果
我们纳入了159例患者（63例累及结肠的克罗恩病患者和96例溃疡性结肠炎患者）。我们发现梅奥内镜子评分系统与溃疡性结肠炎的组织学活动度之间存在显著相关性，而在克罗恩病患者中未发现相关性。患者报告的结果显示，在克罗恩病中与内镜和组织学活动度呈负相关（r = -0.67；r = -0.72），而在溃疡性结肠炎中呈正相关（r = 0.84；r = 0.75）。患者报告的结果是评估溃疡性结肠炎患者疾病活动度的实用且非侵入性工具，但不适用于克罗恩病患者。
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