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基于模型的撤机试验用于 VA-ECLS 治疗。

Model-Based Weaning Tests for VA-ECLS Therapy.

机构信息

University of Liège, GIGA-In Silico Medicine, Belgium.

University of Liège, GIGA-Cardiovascular Sciences, Belgium.

出版信息

Comput Math Methods Med. 2020 Apr 6;2020:4503919. doi: 10.1155/2020/4503919. eCollection 2020.

DOI:10.1155/2020/4503919
PMID:32328151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7165357/
Abstract

Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS. In this study, a patient-specific model of the cardiovascular system connected to a VA-ECLS is built to improve the understanding of this complex system. Pig experiments are performed to validate the model, and the results are quite promising since the mean difference between experimental data and simulation is smaller than 5% for all the hemodynamic quantities. It is also a major objective of this paper to provide a proof-of-concept analysis that model-based approaches could improve the weaning strategy for VA-ECLS therapy.

摘要

体外膜肺氧合（VA-ECLS）在重症监护病房（ICU）中用于治疗急性和严重心源性休克的最极端表现，临床医生必须处理的主要问题之一是从 VA-ECLS 脱机。在这项研究中，建立了一个连接到 VA-ECLS 的心血管系统的患者特定模型，以提高对这个复杂系统的理解。进行了猪实验来验证该模型，结果非常有希望，因为所有血流动力学参数的实验数据与模拟数据之间的平均差异都小于 5%。本文的另一个主要目标是提供概念验证分析，证明基于模型的方法可以改进 VA-ECLS 治疗的脱机策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/94fa0df05a47/CMMM2020-4503919.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/f27608d58e35/CMMM2020-4503919.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/5785a07a8a8f/CMMM2020-4503919.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/8f3cca4ee55f/CMMM2020-4503919.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/b5d4116c7665/CMMM2020-4503919.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/94fa0df05a47/CMMM2020-4503919.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/f27608d58e35/CMMM2020-4503919.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/5785a07a8a8f/CMMM2020-4503919.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/8f3cca4ee55f/CMMM2020-4503919.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/b5d4116c7665/CMMM2020-4503919.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de68/7165357/94fa0df05a47/CMMM2020-4503919.005.jpg

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本文引用的文献

1
A comparison between four techniques to measure cardiac output.
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:2717-2720. doi: 10.1109/EMBC.2016.7591291.
2
Practical identifiability analysis of a minimal cardiovascular system model.实用可识别性分析的最小心血管系统模型。
Comput Methods Programs Biomed. 2019 Apr;171:53-65. doi: 10.1016/j.cmpb.2017.01.005. Epub 2017 Jan 17.
3
Online cardiac output estimation during transvalvular left ventricular assistance.经瓣膜左心室辅助期间的在线心输出量估计。
Comput Methods Programs Biomed. 2019 Apr;171:87-97. doi: 10.1016/j.cmpb.2016.08.020. Epub 2016 Aug 30.
4
Individualized real-time clinical decision support to monitor cardiac loading during venoarterial ECMO.用于在静脉-动脉体外膜肺氧合期间监测心脏负荷的个体化实时临床决策支持。
J Transl Med. 2016 Jan 6;14:4. doi: 10.1186/s12967-015-0760-1.
5
Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock.在猪心源性休克模型中，增加静脉-动脉体外膜肺氧合流量会对左心室功能产生负面影响。
J Transl Med. 2015 Aug 15;13:266. doi: 10.1186/s12967-015-0634-6.
6
Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score.预测 ECMO 治疗难治性心源性休克后的生存率：静脉-动脉-体外膜肺氧合（VA-ECMO）后生存率评分（SAVE 评分）。
Eur Heart J. 2015 Sep 1;36(33):2246-56. doi: 10.1093/eurheartj/ehv194. Epub 2015 Jun 1.
7
Model-based computation of total stressed blood volume from a preload reduction manoeuvre.
Math Biosci. 2015 Jul;265:28-39. doi: 10.1016/j.mbs.2015.03.015. Epub 2015 Apr 10.
8
How to wean a patient from veno-arterial extracorporeal membrane oxygenation.如何使患者从静脉-动脉体外膜肺氧合中撤机。
Intensive Care Med. 2015 May;41(5):902-5. doi: 10.1007/s00134-015-3663-y. Epub 2015 Jan 27.
9
Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock.静脉-动脉体外膜肺氧合在急性心肌梗死合并心源性休克中的疗效。
Resuscitation. 2012 Aug;83(8):971-5. doi: 10.1016/j.resuscitation.2012.01.037. Epub 2012 Feb 6.
10
Validation of subject-specific cardiovascular system models from porcine measurements.从猪的测量数据中验证特定于主体的心血管系统模型。
Comput Methods Programs Biomed. 2013 Feb;109(2):197-210. doi: 10.1016/j.cmpb.2011.10.013. Epub 2011 Nov 27.