Kozlovskaya Liubov I, Golinets Anastasia D, Eletskaya Anastasia A, Orlov Alexey A, Palyulin Vladimir A, Kochetkov Sergey N, Alexandrova Liudmila A, Osolodkin Dmitry I
Institute of Poliomielitis and Viral Encephalitides FSBSI Chumakov FSC R&D IBP RAS Poselok Instituta Poliomielita, 8 bd. 1, Poselenie Moskovsky Moscow 108819 Russia.
Sechenov First Moscow State Medical University, Trubetskaya ul., 8 Moscow 119991 Russia.
ChemistrySelect. 2018 Feb 28;3(8):2321-2325. doi: 10.1002/slct.201703052. Epub 2018 Feb 27.
The rational design of broad-spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of and genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed -hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick-borne encephalitis virus. Furano[2, 3-]pyrimidine nucleosides with -pentyl or -hexyl tails showed selective inhibition of representatives. 5-(Tetradec-1-yn-1-yl)-uridine showed selective inhibition of tick-borne encephalitis virus at the micromolar level.
广谱抗病毒药物的合理设计需要有关化合物针对多种病毒的抗病毒活性数据，而这些数据往往难以获得。我们开发了一组由 属和 属成员组成的（+）单链RNA病毒，用于研究这些活性谱。一组核苷类似物的抗病毒活性分析表明，-羟基胞苷是柯萨奇病毒和其他肠道病毒复制的有效抑制剂，但对蜱传脑炎病毒无效。带有-戊基或-己基尾部的呋喃并[2, 3-]嘧啶核苷对 代表病毒表现出选择性抑制作用。5-（十四烷基-1-炔-1-基）尿苷在微摩尔水平上对蜱传脑炎病毒表现出选择性抑制作用。
