Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5031, Cincinnati, OH, 45229-3026, USA.
Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Abdom Radiol (NY). 2020 Nov;45(11):3709-3715. doi: 10.1007/s00261-020-02536-0.
Little is known about the relationships between MRI splenic T1 relaxation measurements and other radiologic and clinical markers of chronic liver disease, including the presence of radiologic portal hypertension.
To evaluate the relationships between MRI splenic T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis, including the presence of radiologic portal hypertension, in children and young adults with autoimmune liver diseases (AILD).
Research MRI examinations performed at 1.5 T from 63 AILD registry participants were identified. Spleen T1 and iron-corrected T1 (cT1) relaxation measurements, liver cT1, liver/spleen stiffness, splenic length percentile for age, and presence of radiologic portal hypertension were recorded, along with demographic and laboratory data. The Mann-Whitney U test was used to compare continuous data between groups; Spearman correlation was used to evaluate associations. Areas-under-the-receiver operating characteristic curve (AuROC) was used to assess diagnostic performance.
Mean age was 15.2 ± 4.1 years. Mean splenic T1 and cT1 values for the study population were 1158.0 ± 70.9 ms and 1436.0 ± 68.9 ms, respectively. Splenic T1 and cT1 values positively correlated with APRI and FIBROSIS-4 scores, splenic length percentile, liver cT1 values, and liver and spleen stiffnesses (p-values < 0.05). There was no significant relationship between splenic T1/cT1 and age (p-values > 0.05). Splenic T1 and cT1 values were higher in participants with vs. without radiologic portal hypertension (n = 18) (1213.4 ± 69.6 vs. 1135.4 ± 58.5 ms; p = 0.0001, and 1488.2 ± 64.8 vs. 1415.1 ± 59.1 ms; p = 0.0002). Splenic T1 and cT1 both demonstrated an AuROC of 0.81 for discriminating patients without and with portal hypertension (p-values < 0.0001).
Splenic T1 relaxation is associated with other radiologic and clinical biomarkers of liver fibrosis, including radiologic portal hypertension, in children and young adults with AILD.
关于 MRI 脾脏 T1 弛豫测量值与慢性肝病的其他放射学和临床标志物之间的关系，包括存在放射学门脉高压，人们知之甚少。
评估 MRI 脾脏 T1 弛豫与其他肝纤维化的放射学和临床生物标志物（包括存在放射学门脉高压）之间的关系，这些标志物在自身免疫性肝病（AILD）的儿童和年轻成人中。
从 63 名 AILD 登记参与者中确定了在 1.5T 进行的研究性 MRI 检查。记录了脾脏 T1 和铁校正 T1（cT1）弛豫测量值、肝脏 cT1、肝脏/脾脏硬度、年龄脾脏长度百分位数和放射学门脉高压的存在，以及人口统计学和实验室数据。使用 Mann-Whitney U 检验比较组间连续数据；使用 Spearman 相关评估相关性。受试者工作特征曲线下面积（AuROC）用于评估诊断性能。
平均年龄为 15.2±4.1 岁。研究人群的脾脏 T1 和 cT1 值分别为 1158.0±70.9ms 和 1436.0±68.9ms。脾脏 T1 和 cT1 值与 APRI 和 FIBROSIS-4 评分、脾脏长度百分位数、肝脏 cT1 值以及肝脏和脾脏硬度呈正相关（p 值均<0.05）。脾脏 T1/cT1 与年龄无显著相关性（p 值均>0.05）。与无放射学门脉高压（n=18）的参与者相比，有放射学门脉高压的参与者的脾脏 T1 和 cT1 值更高（1213.4±69.6 与 1135.4±58.5ms；p=0.0001，和 1488.2±64.8 与 1415.1±59.1ms；p=0.0002）。脾脏 T1 和 cT1 均具有用于区分无门脉高压和有门脉高压患者的 AuROC 为 0.81（p 值均<0.0001）。
在患有 AILD 的儿童和年轻成人中，脾脏 T1 弛豫与其他肝纤维化的放射学和临床生物标志物（包括放射学门脉高压）相关。
