Federal Research Center Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
Siberian Federal University, Krasnoyarsk, Russia.
Bull Exp Biol Med. 2020 Apr;168(6):789-792. doi: 10.1007/s10517-020-04803-y. Epub 2020 Apr 23.
We studied the distribution of ferrihydrite nanoparticles isolated from bacteria Klebsiella oxytoca in the whole body in vivo and in a cultured isolated organ (liver). The possibility of controlling these nanoparticles in the body using a magnetic field was assessed. One hour after intravenous injection of ferrihydrite nanoparticles to mice, their accumulation was observed in the liver, lungs, and kidneys. Experiment with cultured isolated rat liver showed that these nanoparticles can be controlled by a magnetic field and the influence of magnetic nanoparticles on the liver over 1 h does not lead to destruction of liver cells associated with the release of the marker enzyme AST. These results show the possibility of using magnetic nanoparticles as a system for controlled drug delivery in the body.
我们研究了从产碱杆菌属（Klebsiella oxytoca）中分离的水铁矿纳米颗粒在体内和培养的分离器官（肝脏）中的全身分布，并评估了使用磁场控制这些纳米颗粒在体内的可能性。在将水铁矿纳米颗粒静脉注射到小鼠体内 1 小时后，观察到它们在肝脏、肺和肾脏中的积累。对培养的分离大鼠肝脏的实验表明，这些纳米颗粒可以通过磁场进行控制，并且磁场对肝脏的影响在 1 小时内不会导致与标记酶 AST 释放相关的肝细胞破坏。这些结果表明，使用磁性纳米颗粒作为体内药物控释系统的可能性。
