Research Institute of Human Morphology, Moscow, Russia.
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2020 Apr;168(6):807-811. doi: 10.1007/s10517-020-04807-8. Epub 2020 Apr 23.
Postmortem changes occurring in human carotid body were simulated on the Wistar rat model. It was shown that light, dark, and pyknotic (progenitor) subtypes of human carotid body cells are an artifact and cannot be used in clinical practice to study the characteristics of various human diseases. The differences between the control group of healthy individuals and individuals with the various pathologies are most likely due to the different levels of premortal hypoxia that the tissue had been exposed to. Moreover, widespread antigens used in practice were divided into 2 groups by their tolerance to autolysis: stable and unstable ones. This can be useful for the development of immunohistochemical test algorithms for the diagnostics on autopsy material.
人体颈动脉体的死后变化在 Wistar 大鼠模型上进行了模拟。结果表明，人类颈动脉体细胞的光、暗和固缩（祖细胞）亚型是一种假象，不能在临床实践中用于研究各种人类疾病的特征。健康个体对照组和患有各种病理的个体之间的差异很可能是由于组织生前缺氧程度不同所致。此外，广泛应用于实践的抗原根据其对自溶的耐受性分为 2 组：稳定和不稳定的。这对于开发用于尸检材料诊断的免疫组织化学测试算法可能很有用。
