Lomonosov Moscow State University, 119991 Leninskie Gory, 1/3, Moscow, Russian Federation.
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 119991 Vavilova, 28, GSP-1, Moscow, Russian Federation.
Dalton Trans. 2020 May 19;49(19):6249-6258. doi: 10.1039/d0dt00645a.
Copper-based radiopharmaceuticals are of high interest these days owing to the decay properties of copper radioisotopes. In contrast, labeled zinc compounds have been less studied for applications in nuclear medicine. In this study, the stability of labeled zinc and copper complexes with two azacrown ether ligands was investigated and compared. Then, the in vitro and in vivo stability of the studied zinc complexes was demonstrated, with the complexes showing promise for biomedical applications. In contrast, analogous copper complexes quickly dissociated in the presence of serum proteins. Furthermore, a simple method for the production of radiochemically pure 65Zn was proposed, and the opportunity for its use as a surrogate radionuclide for research into potential zinc-containing radiopharmaceuticals was demonstrated.
由于铜放射性同位素的衰变特性，目前基于铜的放射性药物受到了广泛关注。相比之下，标记锌化合物在核医学应用中的研究较少。在这项研究中，研究了两种氮杂冠醚配体标记的锌和铜配合物的稳定性，并进行了比较。然后，证明了所研究的锌配合物在体外和体内的稳定性，这些配合物有望用于生物医学应用。相比之下，类似的铜配合物在血清蛋白存在下迅速解离。此外，还提出了一种生产放射化学纯 65Zn 的简单方法，并证明了其可作为研究潜在含锌放射性药物的替代放射性核素的机会。
