硫酸乙酰肝素蛋白聚糖-4：内皮糖萼的主要参与者还是无辜旁观者？
Syndecan-4: major player or innocent bystander of the endothelial glycocalyx?
机构信息
Department of Cellular Biology and Anatomy, Lousiana Health Shreveport, Louisiana, USA.
出版信息
Kidney Int. 2020 May;97(5):858-860. doi: 10.1016/j.kint.2020.01.040.
Abstract
Glycocalyces are the pericellular coat of glycoproteins, glycolipids, and proteoglycans. Yet the exploration of glycocalyx function is still ongoing because of the availability of investigative tools capable of discerning the function of one component without inflicting collateral changes in the organization/function of other constituents. The current report by Ramnath et al. explores the function of one family of molecules, the syndecans, as potential regulators of endothelial cell glycocalyx thickness in normal and diabetic glomeruli.
摘要
糖萼是糖蛋白、糖脂和蛋白聚糖的细胞周被。然而，由于缺乏能够在不引起其他成分的组织结构/功能发生附带变化的情况下识别一个成分的功能的研究工具，糖萼功能的探索仍在进行中。Ramnath 等人的最新报告探讨了一个分子家族——黏附素家族——在正常和糖尿病肾小球内皮细胞糖萼厚度中的潜在调节作用。
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