Schlag P, Herrmann R, Raeth V, Lehner B, Schwarz V, Herfarth C
Department of Medicine, Cross Cancer Institute, Edmonton.
Acta Oncol. 1988;27(6b):811-4. doi: 10.3109/02841868809094363.
Forty-two patients with localized squamous cell carcinoma of the esophagus were treated according to a phase II study with cisplatin, vindesine and bleomycin (modified Kelsen schedule) prior to surgery. In 17 of these patients partial remission was achieved and in two cases complete remission. Of the 40 patients who were candidates for surgery, 4 were inoperable. In 22 cases the tumor was removed in a potentially curative manner and in 14 patients a palliative resection was performed. There were 4 post-operative deaths among 36 resected patients. Anastomic leakage occurred in 5 and severe cardiopulmonary complications in 4 patients. The side effects of the preoperative treatment were acceptable. A high resectability rate and a comparatively high survival rate in patients who responded to chemotherapy suggest that the preoperative treatment employed might be of value.
42例局限性食管鳞状细胞癌患者在手术前按照一项II期研究方案接受了顺铂、长春地辛和博来霉素治疗（改良凯尔森方案）。其中17例患者实现部分缓解，2例患者实现完全缓解。在40例适合手术的患者中，4例无法手术。22例患者的肿瘤得以根治性切除，14例患者进行了姑息性切除。36例接受切除的患者中有4例术后死亡。5例发生吻合口漏，4例出现严重心肺并发症。术前治疗的副作用可以接受。化疗有反应的患者具有较高的可切除率和相对较高的生存率，这表明所采用的术前治疗可能有价值。
