Green J, Montasser M
Department of Statistics and Computational Mathematics, The University, Liverpool, England.
Biometrics. 1988 Dec;44(4):941-50.
Previous work on the inheritance of disease has often used certain measures of HLA haplotype concordance (such as the number of haplotypes "identical by descent," IBD) among affected siblings from each of a number of sibships, each of which contains at least two affected siblings. Here we introduce a new measure of HLA haplotype discordance between the affected and unaffected siblings of each sibship (provided there is at least one of each). We show how the measure can be used to give a simple test for inheritance, which we exemplify with data.
先前关于疾病遗传的研究常常采用某些HLA单倍型一致性的测量方法（例如“同源相同”单倍型的数量，即IBD），这些方法是针对多个同胞组中每个同胞组里的患病同胞，每个同胞组至少包含两个患病同胞。在此，我们引入了一种新的测量方法，用于测量每个同胞组中患病同胞与未患病同胞之间的HLA单倍型不一致性（前提是每组中至少各有一个）。我们展示了如何使用该测量方法进行简单的遗传测试，并通过数据进行了举例说明。
