Miao Xiaohui, Yuan Pingqiao, Zhao Lihong, Zhang Le, Jiang Xinyue, Cao Hanyu, Shi Hongrui, Li Jinmei, Yang Rong
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan.
Department of Neurology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou.
Medicine (Baltimore). 2020 Apr;99(17):e19802. doi: 10.1097/MD.0000000000019802.
To identify the risk factors of pneumonia in patients with Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis.This is a retrospective study.Department of Neurology in West China Hospital of Sichuan University.Patients with a definitive diagnosis of anti-NMDA receptor encephalitis.Risk factors associated with pneumonia were examined by bivariate analysis and multivariate logistic regression model.A total of 104 patients were included in this study, of which 41% patients (n = 43) were diagnosed with pneumonia at 7 days (range: 4-40 days) after admission. The occurrence of pneumonia was associated with prolonged hospital stays, a higher rate of poor outcome, and extra healthcare costs. Risk factors associated with pneumonia included Glasgow coma scale score (GCS), abnormal movements and hypokalemia.Pneumonia is a common complication in anti-NMDA receptor encephalitis. In the present study, we found that disorders of consciousness, abnormal movements, and hypokalemia were independent risk factors for pneumonia in inpatients with anti-NMDA receptor encephalitis. Pneumonia prolongs the patients' hospital stay, hospitalization expenditures, and affects the patients' prognosis.
识别抗N-甲基-D-天冬氨酸（抗-NMDA）受体脑炎患者发生肺炎的危险因素。这是一项回顾性研究。四川大学华西医院神经内科。确诊为抗-NMDA受体脑炎的患者。通过双变量分析和多因素逻辑回归模型检查与肺炎相关的危险因素。本研究共纳入104例患者，其中41%（n = 43）的患者在入院后7天（范围：4 - 40天）被诊断为肺炎。肺炎的发生与住院时间延长、不良预后发生率较高以及额外的医疗费用相关。与肺炎相关的危险因素包括格拉斯哥昏迷量表评分（GCS）、异常运动和低钾血症。肺炎是抗-NMDA受体脑炎的常见并发症。在本研究中，我们发现意识障碍、异常运动和低钾血症是抗-NMDA受体脑炎住院患者发生肺炎的独立危险因素。肺炎会延长患者的住院时间、增加住院费用，并影响患者的预后。
