Ackerman S H, Keller S E, Schleifer S J, Shindledecker R D, Camerino M, Hofer M A, Weiner H, Stein M
Department of Psychiatry, New York Hospital/Cornell Medical Center, White Plains 10605.
Brain Behav Immun. 1988 Jun;2(2):161-5. doi: 10.1016/0889-1591(88)90016-5.
Premature separation of rat pups from their mothers, on postnatal Day 15, produced a decreased response of peripheral blood lymphocytes to phytohemagglutinin (PHA) at 40 days of age. A significant lymphopenia was also found in the early weaned animals at 40 days of age although this was accounted for statistically by their lower body weight. These consequences of early maternal separation may have been mediated through the effects of early separation on nutritional state, hypothalamic function, or maturation of the immune system.
在出生后第15天将幼鼠与其母亲过早分离，会导致40日龄时外周血淋巴细胞对植物血凝素（PHA）的反应降低。在40日龄的早期断奶动物中也发现了显著的淋巴细胞减少，尽管从统计学角度来看，这是由它们较低的体重造成的。早期母婴分离的这些后果可能是通过早期分离对营养状况、下丘脑功能或免疫系统成熟的影响介导的。
