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高温腹腔内化疗(HIPEC)在小儿肉瘤中的应用以实现最大程度的肿瘤控制。

Use of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Pediatric Sarcoma for Maximal Oncologic Control.

作者信息

Findlay Bridget L, Gargollo Patricio C, Granberg Candace F

机构信息

Mayo Clinic, Department of Urology, Rochester, MN.

Mayo Clinic, Department of Urology, Rochester, MN.

出版信息

Urology. 2020 Jul;141:139-142. doi: 10.1016/j.urology.2020.04.032. Epub 2020 Apr 22.

Abstract

Few centers worldwide have trialed cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in pediatric rhabdomyosarcoma. This case involves a 5-year-old boy with gross hematuria who was found to have an 8 cm pelvic mass, likely arising from the prostate and extending along the bladder wall. Excisional biopsy revealed undifferentiated fusion negative sarcoma. The mass demonstrated reduction in size with chemotherapy and photon radiation therapy. He presented to our institution for delayed primary excision, and underwent cytoreductive surgery with hyperthermic intraperitoneal chemotherapy using cisplatin. Follow-up imaging 15 months postoperatively demonstrates no evidence of disease.

摘要

全球很少有中心对小儿横纹肌肉瘤进行减瘤手术和腹腔内热化疗。该病例为一名5岁男孩,有肉眼血尿,发现盆腔有一个8厘米的肿块,可能起源于前列腺并沿膀胱壁延伸。切除活检显示未分化融合阴性肉瘤。该肿块经化疗和光子放射治疗后体积缩小。他到我们机构接受延迟一期切除,并使用顺铂进行了减瘤手术和腹腔内热化疗。术后15个月的随访影像显示无疾病迹象。

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