J Pediatr Health Care. 2020 May-Jun;34(3):256-263. doi: 10.1016/j.pedhc.2019.12.007.
Although there are many etiologies for delayed puberty in adolescent-aged girls, the pediatric provider should consider primary ovarian insufficiency if estradiol remains undetectable despite elevated levels of gonadotropins. Adolescent girls with this diagnosis will need holistic care from their primary care provider, focusing on both their medical and psychosocial needs. The following case study describes a 14-year-old girl who was referred to pediatric endocrinology for delayed puberty, in the setting of increased gonadotropins and undetectable estradiol. The differential diagnosis, evaluation, and management of primary ovarian insufficiency are reviewed as well as potential long-term health considerations.
尽管青春期女孩的青春期延迟有许多病因，但如果雌激素水平仍检测不到，而促性腺激素水平升高，儿科医生应考虑原发性卵巢功能不全。患有这种疾病的青春期女孩需要初级保健医生提供全面的护理，既要关注其医疗需求，也要关注其心理社会需求。本病例研究介绍了一名 14 岁女孩，因青春期延迟，促性腺激素升高而雌激素水平检测不到，被转至儿科内分泌科。本文还回顾了原发性卵巢功能不全的鉴别诊断、评估和管理以及潜在的长期健康考虑。
