OncoWitan, Lille (Wasquehal), 59290, France.
Pathol Res Pract. 2020 Jun;216(6):152946. doi: 10.1016/j.prp.2020.152946. Epub 2020 Apr 3.
The anticancer properties of several labdane diterpenes have been well characterized, notably for andrographolide and sclareol. In contrast, the structurally related natural product coronarin D (CRD), principally isolated from the ginger Hedychium coronarium, is much less known. Recently, different studies have underlined the anticancer activities of CRD and in particular its capacity to inhibit the growth and to induce the death of glioblastoma and carcinoma cell lines in vitro. The present review provides a global view of the activities and mechanism of action of CRD and the analogy with the other anticancer labdane diterpenes. CRD exerts its antiproliferative action via an activation of the MAPK pathway, notably by a stimulation of ERK/JNK phosphorylation, which subsequently leads to drug-induced inhibition of cell proliferation and activation of the intrinsic apoptotic pathway. Reactive oxygen species also play a role in the bioactivity of drug, but no well-defined molecular target has been characterized yet. CRD presents an interesting activity profile in vitro and warrants in vivo evaluations, notably for the treatment of glioblastoma.
几种角鲨烷二萜的抗癌特性已经得到了很好的描述，特别是对于穿心莲内酯和鼠尾草醇。相比之下，结构上相关的天然产物冠状素 D（CRD），主要从姜科植物姜黄中分离得到，人们对它的了解要少得多。最近，不同的研究强调了 CRD 的抗癌活性，特别是它抑制体外神经胶质瘤和癌细胞系生长和诱导其死亡的能力。本综述提供了 CRD 的活性和作用机制的全面概述，并与其他抗癌角鲨烷二萜进行了比较。CRD 通过激活 MAPK 途径发挥其抗增殖作用，特别是通过刺激 ERK/JNK 磷酸化，随后导致药物诱导的细胞增殖抑制和内在凋亡途径的激活。活性氧也在药物的生物活性中发挥作用，但尚未确定明确的分子靶点。CRD 在体外具有有趣的活性谱，值得进行体内评估，特别是用于治疗神经胶质瘤。
