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本文引用的文献

1
Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.尼古丁通过抑制 SIRT6 促进神经元存活并部分预防帕金森病。
Acta Neuropathol Commun. 2018 Nov 8;6(1):120. doi: 10.1186/s40478-018-0625-y.
2
Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.α7 型烟碱型乙酰胆碱受体通过钙激活生长锥中的钙蛋白酶来抑制轴突生长。
PLoS One. 2018 May 16;13(5):e0197247. doi: 10.1371/journal.pone.0197247. eCollection 2018.
3
Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.烟碱型乙酰胆碱受体通过前额叶皮质中间部的可塑性控制联想识别记忆的编码和检索。
Cell Rep. 2018 Mar 27;22(13):3409-3415. doi: 10.1016/j.celrep.2018.03.016.
4
Ionotropic and Metabotropic Mechanisms of Allosteric Modulation of 7 Nicotinic Receptor Intracellular Calcium.7 型烟碱型乙酰胆碱受体变构调节的离子型和代谢型机制：细胞内钙离子。
Mol Pharmacol. 2018 Jun;93(6):601-611. doi: 10.1124/mol.117.111401. Epub 2018 Mar 27.
5
Human nicotinic receptors in chromaffin cells: characterization and pharmacology.人嗜铬细胞烟碱受体：特征和药理学。
Pflugers Arch. 2018 Jan;470(1):21-27. doi: 10.1007/s00424-017-2073-0. Epub 2017 Oct 20.
6
Acetylcholine nicotinic receptor subtypes in chromaffin cells.嗜铬细胞中的烟碱型乙酰胆碱受体亚型。
Pflugers Arch. 2018 Jan;470(1):13-20. doi: 10.1007/s00424-017-2050-7. Epub 2017 Aug 8.
7
α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line.α9-和α7 型受体介导尼古丁在 A549 腺癌细胞系中的促增殖作用。
Br J Pharmacol. 2018 Jun;175(11):1957-1972. doi: 10.1111/bph.13954. Epub 2017 Sep 8.
8
α9-containing nicotinic acetylcholine receptors and the modulation of pain.α9 型烟碱型乙酰胆碱受体与疼痛的调制。
Br J Pharmacol. 2018 Jun;175(11):1915-1927. doi: 10.1111/bph.13931. Epub 2017 Jul 30.
9
α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour.α9烟碱型乙酰胆碱受体基因敲除小鼠表现出应激反应、情感及奖赏相关行为的调节异常。
Behav Brain Res. 2017 Jun 15;328:105-114. doi: 10.1016/j.bbr.2017.04.005. Epub 2017 Apr 10.
10
Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens.α7 型烟碱型乙酰胆碱受体缺失导致的抑郁样表型：在伏隔核中脑源性神经营养因子-TrkB 的作用。
Sci Rep. 2016 Nov 8;6:36705. doi: 10.1038/srep36705.

PC12 细胞的烟碱型乙酰胆碱受体。

Nicotinic Acetylcholine Receptors of PC12 Cells.

机构信息

Biology Department, School of Sciences and Humanities, Nazarbayev University, NurSultan, Republic of Kazakhstan.

出版信息

Cell Mol Neurobiol. 2021 Jan;41(1):17-29. doi: 10.1007/s10571-020-00846-x. Epub 2020 Apr 25.

DOI:10.1007/s10571-020-00846-x
PMID:32335772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11448595/
Abstract

Nicotinic acetylcholine receptors (nAChRs) have gained much attention in the scientific community since they play a significant role in multiple physiological and pathophysiological processes. Multiple approaches to study the receptors exist, with characterization of the receptors' functionality at a single cellular level using cell culturing being one of them. Derived from an adrenal medulla tumor, PC12 cells express nicotinic receptor subunits and form functional nicotinic receptors. Thus, the cells offer a convenient environment to address questions related to the functionality of the receptors. The review summarizes the findings on nicotinic receptors' expression and functions which were conducted using PC12 cells. Specific focus is given to α3-containing receptors as well as α7 receptor. Critical evaluation of findings is provided alongside insights into what can still be learned about nAChRs, using PC12 cells.

摘要

烟碱型乙酰胆碱受体（nAChRs）在科学界受到了广泛关注，因为它们在多种生理和病理生理过程中发挥着重要作用。目前有多种研究受体的方法，其中之一是在细胞培养水平上对受体的功能进行特征描述。PC12 细胞来源于肾上腺髓质肿瘤，表达烟碱受体亚单位并形成功能性烟碱受体。因此，这些细胞提供了一个方便的环境来解决与受体功能相关的问题。本综述总结了使用 PC12 细胞进行的烟碱受体表达和功能的研究结果。特别关注含有α3 的受体以及α7 受体。提供了对这些发现的批判性评估，并深入了解使用 PC12 细胞还可以了解 nAChRs 的哪些方面。